December 2002
Volume 43, Issue 13
Free
ARVO Annual Meeting Abstract  |   December 2002
Screening for Glaucoma With a Simplified Version of the Pattern ERG Called PERGLA: 49% of Glaucoma Suspects With Abnormal Disk and Normal IOP and Visual Field Have an Abnormal Response
Author Affiliations & Notes
  • LM Ventura
    Ophthalmology Bascom Palmer Eye Institute Miami FL
  • D Lemus
    Bascom Palmer Eye Inst Miami FL
  • RK Parrish
    Bascom Palmer Eye Inst Miami FL
  • V Porciatti
    Bascom Palmer Eye Inst and Inst Neurophysiol CNR Pisa Miami FL
  • Footnotes
    Commercial Relationships   L.M. Ventura, None; D. Lemus, None; R.K. Parrish, None; V. Porciatti, Lace Electronics, Pisa Italy F.
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 306. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      LM Ventura, D Lemus, RK Parrish, V Porciatti; Screening for Glaucoma With a Simplified Version of the Pattern ERG Called PERGLA: 49% of Glaucoma Suspects With Abnormal Disk and Normal IOP and Visual Field Have an Abnormal Response . Invest. Ophthalmol. Vis. Sci. 2002;43(13):306.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Abstract: : Purpose: To screen for early Pattern ERG abnormalities in subjects suspected of having glaucoma using a simplified, non-invasive and automated technique called PERGLA. Methods: The PERGLA is recorded simultaneously from both eyes by means of skin electrodes on the lower eyelids, in response to horizontal gratings (1.7 c/d, 25 deg circular field, 95% contrast, 100 cd/sqm mean luminance), alternating at 8.14 Hz. The test lasts 3 minutes (two blocks of 1.5 minutes each) and subjects are allowed to blink freely. The PERGLA amplitude and phase (latency) are automatically evaluated by Discrete Fourier Transform and compared with a database of age-corrected, normative values (n=80 eyes). Amplitude and latency are expressed as deviations from normal in SD units. One hundred and sixty one eyes of 81 patients with no ocular diseases other than glaucoma were tested. Inclusion criteria were: normal visual acuity, IOP < 21 mm Hg and Humphrey visual field Mean Defect (MD)< 3dB, in the presence of increased cupping (vertical C/D ≷ 0.5, or vertical C/D ≷ 0.4 plus at least one of the following: asymmetry ≷ 0.2, disk notching, disk splinter hemorrages, or positive family history). Results: The response amplitude was lower than 2 SDs from normal average in 45/161 eyes (28%) and the latency was longer than 2 SDs in 19/161 eyes (12%). Responses abnormal for both amplitude and latency were 10/161 (6%). Interocular amplitude and latency asymmetries exceeded 2 SDs in 15% and 3% of patients, respectively. Overall, patients with an abnormality in either amplitude/latency or interocular asymmetry were 40/81 (49%). Latency abnormalities increased significantly with age (r squared =0.4). There was no obvious association between amplitude losses and the amount of cupping; however, there was a borderline correlation between amplitude asymmetry and C/D asymmetry (p=0.078). Conclusion: The PERGLA technique detected abnormal responses in 49% of glaucoma suspects with increased cup/disk ratios and normal IOP and visual fields. At six month intervals, we are repeating the PERGLA and visual fields in all patients to determine possible glaucomatous progression.

Keywords: 395 electroretinography: clinical • 415 ganglion cells • 489 neuroprotection 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×