December 2002
Volume 43, Issue 13
Free
ARVO Annual Meeting Abstract  |   December 2002
Ginkgo Biloba Extract Does Not Alter Peripapillary Retinal Hemodynamics Using Heidelberg Retina Flowmetry In Open Angle Glaucoma
Author Affiliations & Notes
  • R Gurses-Ozden
    New York Eye & Ear Infirmary New York NY and New York Medical College Valhalla NY
  • A Harris
    Indiana University School of Medicine Indianapolis IN
  • S Piette
    New York Eye & Ear Infirmary New York NY and New York Medical College Valhalla NY
  • LE Kagemann
    Indiana University School of Medicine Indianapolis IN
  • H Ishikawa
    New York Eye & Ear Infirmary New York NY and New York Medical College Valhalla NY
  • JM Liebmann
    New York Eye & Ear Infirmary New York NY and New York Medical College Valhalla NY
  • R Ritch
    New York Eye & Ear Infirmary New York NY and New York Medical College Valhalla NY
  • Footnotes
    Commercial Relationships   R. Gurses-Ozden, None; A. Harris, None; S. Piette, None; L.E. Kagemann, None; H. Ishikawa, None; J.M. Liebmann, None; R. Ritch, None. Grant Identification: Support: NY Glauc Res Inst, NY Eye & Ear Infirmary, NY, NY, Fight for Sight Grant, Schaumburg, IL
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 319. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      R Gurses-Ozden, A Harris, S Piette, LE Kagemann, H Ishikawa, JM Liebmann, R Ritch; Ginkgo Biloba Extract Does Not Alter Peripapillary Retinal Hemodynamics Using Heidelberg Retina Flowmetry In Open Angle Glaucoma . Invest. Ophthalmol. Vis. Sci. 2002;43(13):319.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Abstract: : Purpose: To evaluate the effect of Ginkgo biloba extract (GBE) on ocular hemodynamics in open angle glaucoma. Methods: Patients with open angle glaucoma were enrolled in this double-masked, placebo controlled cross-over study. Blood flow in the superior and inferior temporal peripapillary areas was evaluated with Heidelberg Retina Flowmetry (HRF; Heidelberg Engineering, GmbH, Heidelberg, Germany). After baseline measurements, patients were randomly assigned to oral placebo or GBE 120 mg/day. HRF examination was repeated in 3 months, after the first arm of the study, and in 6 months, after crossover arm. No systemic or topical medications were added during this period. Pointwise analysis was used to evaluate HRF images. HRF parameters at baseline and post-GBE and post-placebo were compared by paired t-Test. Results: Forty-one eyes of 23 patients (11 males, 12 females) were enrolled. Mean patient age was 61.9 ± 13.1 years (range, 32-79 years). There was no difference among baseline; post-GBE and post-placebo mean flow, zero-flow pixels (pixels less than one arbitrary unit of flow), 25th, 50th, 75th and 90th percentiles of flow at any location (p≷0.05 for all comparisons; see table). Conclusion: GBE, at a dose of 120mg/day, has no detectable alteration on peripapillary retinal hemodynamics using HRF in open angle glaucoma. Table (*arbitrary units)  

Keywords: 390 drug toxicity/drug effects • 430 imaging/image analysis: clinical • 357 clinical (human) or epidemiologic studies: treatment/prevention assessment/controlled clinical trials 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×