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E Rechtman, A Harris, L Kagemann, B Siesky, LJ McCranor, C Amin, C Cole, C Pesavento, D Weinberger; Area Dilution Analysis of Indocyanine Green Angiography: Validation with Color Doppler Imaging . Invest. Ophthalmol. Vis. Sci. 2002;43(13):330.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose:To compare two methods of measuring hemodynamics in the uveal vasculature. Methods:Hemodynamics in the choroid of 15 normal subjects (27.8 ± 8.9 years) was altered by 60mg PO nicergoline (an alpha adrenergic receptor antagonist). Color Doppler imaging (CDI) measurements of the nasal and temporal posterior ciliary arteries (PCA), and indocyanine green (ICG) angiography were performed at baseline and two hours post-medication. Peak systolic and end diastolic velocities were measured (PSV and EDV) by CDI, and Pourcelot's resistive index (RI) was calculated. ICG angiograms were analyzed by area dilution analysis (ADA), in which the fluorescence of four areas in the perimacular region and two areas in the temporal peripapillary region were graphed during dye filling. Dye arrival times, range in dye arrival times, dye duration, and slopes were quantified from the graph. Results:Percent change of the 10% and 63% filling time in all 6 areas correlated with nasal PCA EDV (p≤ 0.049, r2≥0.502 and p≤ 0.031, r2≥0.566 respectively). The 63% filling time changes correlated with the RI in all areas of the nasal and temporal PCA (p≤ 0.048, r2≥0.504 and p≤ 0.025, r2≥0.75 respectively). In the nasal PCA and temporal PCA, the 10% filling time changes correlated with RI in all perimacular areas and the inferior peripapillary area (p≤ 0.031, r2≥0.56 and p≤ 0.048, r2≥0.66 respectively). Conclusion:Choroidal hemodynamics as described by ADA agree with CDI flow velocity measurements. This angiographic technique enables quantification of peripapillary and perimacular regional hemodynamics.
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