December 2002
Volume 43, Issue 13
Free
ARVO Annual Meeting Abstract  |   December 2002
Estrogen-Replacement Therapy: the Effect of Raloxifene on Retrobulbar Hemodynamics
YM Catoira; A Harris; R Rachmiel; B Kaplan; E Rechtman; R Migliardi; M Zalish
Author Affiliations & Notes
  • YM Catoira
    Ophthalmology Mt Sinai Sch Med New York NY
  • A Harris
    Ophthalmology Indiana Univ Sch of Med Indianapolis IN
  • R Rachmiel
    Ophthalmology Kaplan Med Center Rehovot Israel
  • B Kaplan
    Obstetric&Gynecology Rabin Med Center Petah Tikva Israel
  • E Rechtman
    Ophthalmology Indiana Univ Sch of Med Indianapolis IN
  • R Migliardi
    Ophthalmology Indiana Univ Sch of Med Indianapolis IN
  • M Zalish
    Ophthalmology Kaplan Med Center Rehovot Israel
  • Footnotes
    Commercial Relationships   Y.M. Catoira, None; A. Harris, None; R. Rachmiel, None; B. Kaplan, None; E. Rechtman, None; R. Migliardi, None; M. Zalish, None. Grant Identification: Unrestricted Grant to prevent blindness, NIH EYE 10801
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 333. doi:
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      YM Catoira, A Harris, R Rachmiel, B Kaplan, E Rechtman, R Migliardi, M Zalish; Estrogen-Replacement Therapy: the Effect of Raloxifene on Retrobulbar Hemodynamics . Invest. Ophthalmol. Vis. Sci. 2002;43(13):333.

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Abstract

Abstract: : Purpose: Estrogen-replacement therapy ( ERT ) causes vasodilation and increased blood flow in cerebral vasculature and major peripheral arteries. ERT may enhance ocular circulation by reducing vascular resistance. This study examined the effect of raloxifene(a selective estrogen receptor modulator), an ERT, on retrobulbar hemodynamics in postmenopausal women. Methods: Flow measurements of 30 postmenopausal women receiving 150 mg raloxifene daily were compared to measurements of 29 age-matched postmenopausal women receiving no treatment. Color Doppler imaging (CDI) measured peak systolic (PSV) and end diastolic (EDV) velocities in the ophthalmic (OA) and central retinal arteries (CRA) and the resistive index (RI) (RI = PSV - EDV / PSV). The flow velocity data from the two groups was compared using student's unpaired t-tests. A p value ≤ 0.05 was considered significant. Results: All measured flow velocities were significantly higher in the drug-treated women than the non-treated women (pAll measured flow velocities were significantly higher in the drug-treated women than the non-treated women (p≤0.05) Conclusion: Estrogen-replacement therapy with raloxifene appears to reduce vascular resistance downstream from the OA. This ocular hemodynamic effect may help explain previous reports of a lower prevalence of glaucoma in postmenopausal women receiving ERT compared to postmenopausal women with no treatment.

Keywords: 309 aging • 514 pharmacology 
© 2002, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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