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M Ito, K Murayama, T Gil, I Katzir, M Takasu, T Deguchi, S Yoneya; Effect of Latanoprost on Retinal Hemodynamic Changes in Patients with Glaucoma . Invest. Ophthalmol. Vis. Sci. 2002;43(13):336.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose:To investigate the retinal hemodynamic change in glaucoma patients after topical use of Latanoprost. Methods:Eleven primary open angle glaucoma eyes from 54 to 72 years (mean age: 63.8 years) of age who were never given any glaucoma treatment were studied. Intraocular pressure measurement (IOP), Humphrey field analysis (HFA,program 30-2), confocal scanning laser doppler flowmetry(CLDF), and measurement of oxygen saturation (OS) levels in the fundus were performed in all patients before, one month and three months after topical use of Latanoprost.. The OS levels of the retina were estimated using a spectral retinal imager (ASI Migdal Ha'Emak, Israel). This consists of a fundus camera (Topcon TRC-50IA), Sagnac interferometer with a charge-couple device and acquisition and analysis software modules that are running on a personal computer. OS values in each pixel of the fundus image with a 35- degree view can be estimated from the respective spectrum that is obtained by Fourier-transforming the interferometer signals. OS values were calculated in five retinal points (superior, temporal-superior, temporal-inferior, inferior, and nasal point) and averaged. The mean of blood volume, velocity, and flow obtained from three temporal peripapillary sites in an CLDF image were calculated and analyzed. Results:The average of mean deviation (MD) of HFA was -6.65dB. The average of IOP were 16.9 mmHg before treatment ,13.7mmHg one month after(P<0.01) and 12.8mmHg three months after treatment(P<0.01). Retinal capillary flow calculated by CLDF were 209.9 before treatment, 254.4 one month after(P<0.01) and 228.5 three months after treatment(P<0.05). OS level were 75.8% before treatment and 80.2% one month after treatment. OS level in the retina tended to improve after treatment. There were no drug effect on blood pressure, heart rate, or visual acuity. Conclusion:These results indicate that Latanoprost treatment in POAG patients would cause improvement of retinal flow and retinal oxogen saturation level. Together with retinal blood flow, calculation of oxygen saturation level might be another tool to evaluate retinal hemodynamics.
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