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AJ Kruger, M Amon, J Schauersberger, G Schild, G Bartl, C Abela-Formanek; Comparison of the Biocompatibility of Two Sharp-edge Silicone IOLs With Different Haptic Angulation . Invest. Ophthalmol. Vis. Sci. 2002;43(13):420.
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Purpose: Purpose of this study was to compare the influence of haptic angulation of two similar silicone IOLs on biocompatibility parameters six month after implantation. Methods: In this prospective, randomised, bilateral single surgeon study 15 patients with senile cataract were included. After standardized phacoemulsification and a 5 mm overlapping CCC a Pharmacia 911edge or a Ophthec Oculaid PC420 IOL was implanted. Both IOL are made of silicone, have a 6mm sharp-edge optic and an overall diameter of 12.5mm. The haptic of the 911e is angulated with 8° and the haptic of the Oculaid PC420 is plane. Six month after surgery we evaluated flare-values and cell-values by means of the LFCM-KOWA 1000. Biomicroscopically anterior capsule opacification(ACO) and posterior capsule opacification(PCO) were graded semiquantitatively from grade 0 to 3. Cellular reaction (lens epithelial outgrowth, small round cells, epitheloid cells and foreign body giant cells) on the anterior IOL surface were examined with specular microscopy. Centration of the IOL was graded from 0 to 3. Results: The mean flare and cell-values did not show any statistically differences (6.0+/-2.3 and 5.2+/-1.9). Cellular reaction on both IOLs are comparable (small round cells grade 1 in 3/15 in both groups, epiotheloid cells in 1/15 in each group, no foreign-body-giant cell reaction and no LEC ongrowth in any case). ACO was more pronounced in the 911e-group. Only one grade 1 PCO (central 3 mm) in the 911e-group could be found in contrast to 1 eye wirth grade2 and 4 eyes with grade1 central PCO in the Oculaid PC420-group. Both IOLs showed good centration properties. Conclusion: This six-month results reveal, that haptic angulation might have an impact on PCO incidence. View OriginalDownload SlideView OriginalDownload Slide
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