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JB Holmen, B Ekesten, B Lundgren; Improvements of a Method to Evaluate Ophthalmic Viscosurgical Devices (OVDs) in a Porcine Cadaver Eye Model . Invest. Ophthalmol. Vis. Sci. 2002;43(13):440.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose:To evaluate the effect of different parameters in a porcine cadaver eye model used for evaluation of viscoelastic solutions (ophthalmic viscosurgical devices, OVDs). The aim was to improve the model for identification of differences between OVDs during simulated cataract surgery. Methods:Cataract surgery was performed in fresh porcine cadaver eyes and documented by EAS-1000 Scheimpflug photography. Anterior chamber depth (ACD) measurements were performed. Correlations between eye globe weight, corneal diameter, initial ACD, ACD after OVD injection (Healon®) and ACD after capsulorhexis were studied. Results:Significant correlations (p<0.05) were found between initial ACD and ACDs of latter surgical steps. No significant correlations were found between globe weight or corneal diameter and the ACDs during the surgery. Conclusion:The ACDs during simulated cataract surgery were correlated to the ACD before surgery. In order to reduce variation and increase the precision of the test system when evaluating OVDs, a change in ACD should be expressed as percentage change from initial ACD. However, there was no significant correlation between globe weight, corneal diameter and the ACD during subsequent steps of cataract surgery. Thus, adjusting for globe weight and corneal diameter will not reduce the variation in ACD between eyes.
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