December 2002
Volume 43, Issue 13
ARVO Annual Meeting Abstract  |   December 2002
Improvements of a Method to Evaluate Ophthalmic Viscosurgical Devices (OVDs) in a Porcine Cadaver Eye Model
Author Affiliations & Notes
  • JB Holmen
    Unit of Ophthalmology Faculty of Vet Medicine SLU Uppsala Sweden
  • B Ekesten
    Department of Ophthalmology University of Minnesota Minneapolis MN
  • B Lundgren
    Visionar Biomedical AB Uppsala Sweden
  • Footnotes
    Commercial Relationships   J.B. Holmen, None; B. Ekesten, None; B. Lundgren, Visionar Biomedical AB E.
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 440. doi:
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      JB Holmen, B Ekesten, B Lundgren; Improvements of a Method to Evaluate Ophthalmic Viscosurgical Devices (OVDs) in a Porcine Cadaver Eye Model . Invest. Ophthalmol. Vis. Sci. 2002;43(13):440.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract: : Purpose:To evaluate the effect of different parameters in a porcine cadaver eye model used for evaluation of viscoelastic solutions (ophthalmic viscosurgical devices, OVDs). The aim was to improve the model for identification of differences between OVDs during simulated cataract surgery. Methods:Cataract surgery was performed in fresh porcine cadaver eyes and documented by EAS-1000 Scheimpflug photography. Anterior chamber depth (ACD) measurements were performed. Correlations between eye globe weight, corneal diameter, initial ACD, ACD after OVD injection (Healon®) and ACD after capsulorhexis were studied. Results:Significant correlations (p<0.05) were found between initial ACD and ACDs of latter surgical steps. No significant correlations were found between globe weight or corneal diameter and the ACDs during the surgery. Conclusion:The ACDs during simulated cataract surgery were correlated to the ACD before surgery. In order to reduce variation and increase the precision of the test system when evaluating OVDs, a change in ACD should be expressed as percentage change from initial ACD. However, there was no significant correlation between globe weight, corneal diameter and the ACD during subsequent steps of cataract surgery. Thus, adjusting for globe weight and corneal diameter will not reduce the variation in ACD between eyes.

Keywords: 317 anterior chamber • 386 depth • 431 imaging/image analysis: non-clinical 

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