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H Yanagawa, S Kobayakawa, K Nagamine, T Tochikubo, M Miura; Effect of Silicone Intraocular Lens Design on Posterior Capsule Opacification . Invest. Ophthalmol. Vis. Sci. 2002;43(13):446.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To compare the extent of posterior capsule opacification (PCO) for various designs of silicone intraocular lenses(IOLs) in rabbits. Methods: Japanese albino rabbits (2.0-2.5kg, n=21) were used. Three types of IOLs were prepared. Type A is silicone optic and polyamide loop-haptic IOL with round edge (Canonstaar AQ-2013). Type B is one-piece plate-haptic IOL with round edge (Canonstaar AA-4203F). Type C is one-piece plate-haptic IOL with sharp edge (Canonstaar JAPAN, original type). After phacoemulsification under general anesthesia, IOLs were implanted in seven eyes for each type. Three to four weeks after surgery, eyes were enucleated and the capsular bag was observed and photographed using the vitreous view (Miyake-Apple view). The percentage area of PCO was calculated using domain image processing and analysis software, Scion imageR. Then histopathological examination was performed. Results:The mean percentage area of PCO was 47.14±20.04%(mean ± standard deviation) in Type A IOL group(three-piece round edge, n=7), 60.05±31.92% in Type B IOL group(one piece round edge, n=4) and 42.98±31.42% in Type C IOL group(original one-piece sharp edge, n=7). There was no significant difference in PCO area among the three groups but a tendency was noticed that PCO area of type C IOL group was the smallest of three groups. In histopathological findings, lens epithelial cells (LECs) of type A and type B group migrated to the surface of posterior capsule. With type C IOLs, a sharp capsular bend formed and LECs migration was inhibited in most eyes. Conclusion:The sharp edge design of silicone IOL seems to play a role in preventing LECs from migrating and forming PCO.
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