December 2002
Volume 43, Issue 13
Free
ARVO Annual Meeting Abstract  |   December 2002
Type 2A Juxtafoveolar Telangiectasia in a Family of Monozygotic Twins
Author Affiliations & Notes
  • N Siddiqui
    Ophthalmology
    Duke University Eye Center Durham NC
  • S Fekrat
    Duke University Eye Center Durham NC
  • Footnotes
    Commercial Relationships   N. Siddiqui, None; S. Fekrat, None.
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 506. doi:
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      N Siddiqui, S Fekrat; Type 2A Juxtafoveolar Telangiectasia in a Family of Monozygotic Twins . Invest. Ophthalmol. Vis. Sci. 2002;43(13):506.

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Abstract

Abstract: : Purpose: To report the clinical and fluorescein angiographic characteristics of monozygotic twins and their family members affected by type 2A idiopathic juxtafoveolar telangiectasia Methods: Report of two cases Results: Two 68-year-old Caucasian, monozygotic, female twins were examined. Visual acuity was 20/50-2 OD and 20/40-1 OS. Slit lamp biomicroscopy demonstrated right angle venules without edema OU. Yellow refractile deposits with some fine intraretinal,dot hemorrhage was present OS. No RPE hyperplasia present. Fluorescein angiography demonstrated areas of increasing hyperfluorescence temporal to macula OU consistent with leakage at the level of the retina. Her identical twin sister, with a history of type II diabetes and amblyopia 20/60 OD, presented with a visual acuity 20/60 OD and 20/25 OS. On exam, she had right angled venules OU, refractile deposits OS, and no macular edema OU. No RPE hyperplasia present. Fluorescein angiography demonstrated an area of hyperfluorescence temporal and nasal to macula consistent with leakage at the level of the retina OU. Two daughters of one of the twins were examined and fluorescein angiograms were obtained. One daughter demonstrated a right angled venule OS. Conclusions: This is the second set of female monozygotic twins reported in the literature. One of ours with type 2A idiopathic juxtafoveolar telangiectasia had diabetes. This report further underscores the influence of genetic factors in the pathoetiology of this retinal vascular disease.

Keywords: 554 retina • 354 clinical (human) or epidemiologic studies: prevalence/incidence 
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