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R Haimovici, S Rumelt, J Melby; Endocrine And Metabolic Abnormalities In Central Serous Chorioretinopathy . Invest. Ophthalmol. Vis. Sci. 2002;43(13):530.
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Purpose: To investigate and identify endocrine and metabolic abnormalities in patients with central serous chorioretinopathy (CSCR). Methods: Serum and urinary catecholamines, glucocorticoids, mineralocorticoids, serum testosterone, and thyroid stimulating hormone (TSH) function were evaluated prospectively in patients with active CSCR. Results: Fifty percent (12/24) of patients with active CSCR showed elevated 24-hour urine cortisol or tetrahydroaldosterone levels. Plasma catecholamines were elevated in 7/24 patients although 24-hour urine metanephrines were normal. Serum testosterone and TSH levels were normal in nearly all (23/24) patients. Conclusion: Many patients with CSCR have elevated 24-hour urine corticosteroids, which may contribute to the pathogenesis of the disorder. Endogenous mineralocorticoid dysfunction is a newly described feature of CSCR.
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