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WC Chan, F Ali, KA Muldrew, U Chakravarthy; A comparison of fluorescein leakage in untreated and PDT treated eyes with CNV of AMD . Invest. Ophthalmol. Vis. Sci. 2002;43(13):570.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose:To study the changes in classic and occult fluorescein leakage in CNV of AMD in untreated and photodynamic therapy treated eyes in the short term. Methods:Thirty two angiograms were selected from a database using criteria identified by the TAP study for the best outcome group for verteporfin photodynamic therapy (PDT) . None of these eyes received any treatment. Since the publication of TAP, 55 patients at our centre were considered suitable for PDT and underwent treatment. Angiograms at baseline and 3 months were available for analysis on 29 of this group. All angiograms were analysed using image analytical software and the area of classic and occult CNV were measured at baseline and at the subsequent visit. Results:In the untreated group 65% were wholly classic, 28% predominantly classic and 7% minimally classic or occult. In the PDT treated group, 55% were wholly classic, 35% predominantly classic and 10% minimally classic or occult. In the untreated group at baseline the area of classic leakage was 1.32mm2 +/-0.25, that of occult CNV 0.57 mm2 +/- 0.40. After 3 months the area of classic had expanded by 40% (p < .0001) and the area of occult CNV did not change. In PDT treated eyes at baseline the area of classic CNV was 3.13 mm2 +/- 0.65 and that of occult was 1.82 mm2 +/- 0.53. At the 3 month follow up the paired t test showed that there was a significant reduction in the area of classic leakage (1.50 mm2 +/- 0.52, p < 0.000) but not that of occult leakage (1.75mm2 +/- 0.49, p = 0.38). Conclusion:The short term natural history of classic leakage is one of rapid expansion from initial presentation. Photodynamic therapy has a marked effect and minimises the area of classic leakage. Occult leakage does not change in the short term and nor is it modified by treatment with PDT.
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