December 2002
Volume 43, Issue 13
Free
ARVO Annual Meeting Abstract  |   December 2002
Photodynamic Therapy for Extrafoveal and Juxtafoveal Choroidal Neovascularization
Author Affiliations & Notes
  • SJ Huang
    LuEsther T Mertz Retinal Research Center
    Manhattan Eye Ear and Throat Hospital New York NY
  • LV Del Priore
    Ophthalmology Manhattan Eye Ear and Throat Hospital; Columbia Presbyterian Hospital New York NY
  • C Mendoza
    LuEsther T Mertz Retinal Research Center
    Manhattan Eye Ear and Throat Hospital New York NY
  • JS Slakter
    Lu Ester T Mertz Retinal Research Center
    Manhattan Eye Ear and Throat Hospital New York NY
  • RF Spaide
    LuEsther T Mertz Retinal Research Center
    Manhattan Eye Ear and Throat Hospital New York NY
  • B Freund
    LuEsther T Mertz Retinal Research Center
    Manhattan Eye Ear and Throat Hospital New York NY
  • JA Sorenson
    LuEsther T Mertz Retinal Research Center
    Manhattan Eye Ear and Throat Hospital New York NY
  • DL L Costa
    LuEsther T Mertz Retinal Research Center
    Manhattan Eye Ear and Throat Hospital New York NY
  • N Borodoker
    LuEsther T Mertz Retinal Research Center
    Manhattan Eye Ear and Throat Hospital New York NY
  • LA Yannuzzi
    Lu Ester T Mertz Retinal Research Center
    Manhattan Eye Ear and Throat Hospital New York NY
  • Footnotes
    Commercial Relationships   S.J. Huang, None; L.V. Del Priore, None; C. Mendoza, None; J.S. Slakter, Novartis Ophthalmics C; R.F. Spaide, None; B. Freund, None; J.A. Sorenson, None; D.L.L. Costa, None; N. Borodoker, None; L.A. Yannuzzi, None.
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 581. doi:
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    • Get Citation

      SJ Huang, LV Del Priore, C Mendoza, JS Slakter, RF Spaide, B Freund, JA Sorenson, DL L Costa, N Borodoker, LA Yannuzzi; Photodynamic Therapy for Extrafoveal and Juxtafoveal Choroidal Neovascularization . Invest. Ophthalmol. Vis. Sci. 2002;43(13):581.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To determine the efficacy of photodynamic therapy (PDT) for juxtafoveal or extrafoveal lesions with mainly classic components in age-Related macular degeneration (AMD) and other disorders, in which treating surgeon deferred thermal laser to avoid scotoma. Methods: Retrospective review of pretreatment fluorescein angiograms from April 2000 to December 2001 in a large multiphysician retina practice. Results: Forty-one eyes of 40 patients were reviewed. Age ranged from 35 to 94 (mean =72.2). Treated diseases included: AMD (27 eyes, 65.9%), myopic degeneration (5 eyes, 12.2%), multifocal choroiditis (MFC) (3 eyes of 2 patients, 7.3%), polypoidal choroidal vasculopathy (PCV) (2 eyes, 4.9%), retinal angiomatous proliferation (RAP) (2 eyes, 4.9%), presumed ocular histoplasmosis syndrome (POHS) (1 eye, 2.4%) and idiopathic choroidal neovascularization (ICNV) (1 eye, 2.4%). Pretreatment CNV was predominantly classic in 32 eyes (78%); location was juxtafoveal in 31 eyes (76%) and extrafoveal in 10 eyes (24%). Initial best-corrected Snellen acuity (VA) ranged from 20/25 to 20/1600 (mean =20/200) and final VA ranged from 20/20 to 20/1600 (mean =20/200). The number of treatments ranged from 1 to 6 (mean = 2.4). VA improved by 2 or more lines in 12 eyes (29%), stabilized in 14 (34 %), and decreased 2 or more lines in 15 (37 %). Final VA was 20/100 or better in 19 eyes, including 12 eyes with AMD (44% of original 27 eyes), 2 (40%) with myopic degeneration, 2 (67%) with MFC, 1 (50%) with PCV, 1 (50%) with RAP, 1 (100%) with POHS, and 1 (100%) with ICNV. Conclusion: Treatment of extrafoveal and juxtafoveal lesions with PDT is associated with partial stabilization and improvement of visual acuity in some cases. Approximately 40% of patients with AMD and myopic degeneration achieve a final vision ≷ 20/100. Further research is required to determine the prognosis and response to PDT of patients with extrafoveal and juxtafoveal choroidal neovascularization.

Keywords: 346 choroid: neovascularization • 516 photodynamic therapy • 460 macula/fovea 
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