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W Roquet, D Sayag, F Coscas, W Haddad, S Razavi, G Coscas, G Soubrane; Contribution of Optical Coherence Tomography (OCT) in Retreatment of Subfoveal Choroidal Neovascularization after the First Photodynamic Therapy (PDT) . Invest. Ophthalmol. Vis. Sci. 2002;43(13):585.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To determine the role of OCT, for the retreatment of subfoveal choroïdal neovascularization in age-related macular degeneration with PDT. Methods: A complete ophthalmologic examination including, ETDRS visual acuity measurement , biomicroscopy, fluorescein angiography was performed prospectively in 50 predominantly classic CNV, before and 3 months after the first photodynamic therapy. In addition, 6 OCT radial lines intersecting with the fixation point allowed to obtain a retinal map (software of the OCT-ZEISS HUMPHREY, Germany) and a macular thickness measurement. Results: There is a significative correlation (p= 0.04) at 3 months between the average variation of the central retinal thickness (zone A1) of the retinal map and the indication of retreatment. The late fluorescein angiographic leakage is in all cases correled to the presence of intra or subretinal fluid on the foveal section. In the absence of serous retinal detachment in biomicroscopy and leakage on fluorescein angiography, OCT does not disclose any intra or subretinal fluid, but a certain degree of fibrosis. In other cases, OCT has shown an increase of the mean thickness on the retinal map and the presence of retinal fluid on one section line, used as basis for retreatment indication that was subsequently confirmed by fluorescein leakage. Conclusion: OCT is a noncontact, noninvasive method in order to evaluate the activity of choroïdal neovascularization and degree of subretinal fibrosis. Thus it appears very useful in guiding retreatment decision with photodynamic therapy.
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