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C Jin, J Ge, L Jiang; Photodynamic Therapy with Visudyne for the Treatment of Choroidal Neovascularization in Southern China . Invest. Ophthalmol. Vis. Sci. 2002;43(13):610.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To evaluate safety and effects of photodynamic therapy (PDT) after single treatment with visudyne for choroidal neovascularization (CNV) in age-related macular degeneration (AMD), idiopathic macular choroidal neovascularization and pathological myopia(PM). Method: Forty-eight patients with CNV(30 cases with AMD, 11 cases with idiopathic macular choroidal neovascularization and 7 cases with PM) were involved in this study. They were aged from 23 to 78 years old with the average of 51.3. Twenty-nine cases were male and 19 cases were female. In AMD cases(33 eyes) classic CNV were found in 9 eyes, occult CNV in 16 eyes and mixed CNV in 8 eyes. Best-corrected visual acuity testing, ophthalmic examinations, Humphrey visual field, multi-focal electrical retinography(MERG),fundus color photographs, and fluorescein angiograms were used to evaluate the results of PDT treatment at different time. 6 mg/m2 visudyne dosage was infused for 10 minutes. Diode laser with wavelength of 689nm was used as light source. The light dose of 50 J/cm2 was applied 15 minutes after infusion start. VA, MERG and VF were examed 3 days and 7 days after PDT . FFA was performed 1 week and one month after PDT. Results: 35.3% cases got improved vision, 62.7% cases got stable vision and 2% had decreased vision. Cessation of fluorescein leakage from CNV was achieved in 39.4% of AMD cases, 45.4% of idiopathic macular CNV and 71.4% of PM at one week after PDT, which tended to be decreased one month later. Persistent fluorescein leakage was found to be 18.2% of AMD cases, 9.2% of idiopathic macular CNV at one week after PDT, which tended to be increased one month later. There were no statistically significant differences between MERGs before and after PDT(both at 3 days and 7 days). There was no statistically significant difference between VFs before and after PDT(both at 3 days and 7 days). Conclusion: Photodynamic therapy with visudyne for CNV secondary to AMD, idiopathic macular CNV and PM was safety and effective after single treatment. The controlled CNV lesion tended to be releakage in some cases, which might be necessary to receive repeated PDT.
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