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RA Eiferman, DP Devore, RE Nordquist; Reversible in Situ Formation of a Collagen Canalicular Plug . Invest. Ophthalmol. Vis. Sci. 2002;43(13):68.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To demonstrate a novel rapid formation of a canalicular plug using in situ polymerization of collagen. Method: A patented process produces bovine collagen fibrils which undergo instant fibrillogenesis upon contact with ions. This mixture was injected into the inferior and superior canaliculus of a rabbit. At various time points, the tissue was removed for histology. To test the reversibility of the procedure, collagenase was injected into the punctum to digest the plug Results: Light microscopy demonstrated total occlusion of the canaliculus by polymerized collagen. There was no inflammatory response in surrounding tissue. The plug could be instantly dissolved with collagenase and the canaliculus regained patency. Conclusion: Rapid, in situ polymerization of collagen is feasible method of treating dry eye and is completely reversible.
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