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M Mueller, LE Pillunat, AG Boehm, AS Bernd, AU Koeller, KA Mollenhauer; Precorneal Tear Film Changes After Application Of Topical Alpha Agonists And The Dorzlolamide-timolol Combination . Invest. Ophthalmol. Vis. Sci. 2002;43(13):1071.
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Purpose:To investigate the short time influence of fixed combination of dorzolamide and timolol eye drops and topical alpha-agonists apraclonidine and brimonidine on ocular tear film. Methods:30 healthy subjects (14 male, 16 female; mean age 32years) received in a double masked, cross over design a single dose of the fixed combination of dorzolamide and timolol (CDT), apraclonidine (AC) and brimonidine (BR) in one randomly chosen eye. NaCl 0,9% solution served as control. 60 minutes before and 30, 60 and 90 minutes after eye drop application the tear film break up time (BUT) and basal tear secretion (BTS) were determined. For measuring the BUT 10 µl of 0.2% fluorescein solution was used. BTS measurements were obtained by the Schirmer Test. The Wilcoxon test was used for statistical analysis. Results:The baseline results were normalized to 100% due to considerable interindividual variation: View OriginalDownload SlideView OriginalDownload Slide [T±t in min; mean±SD; (x): Δ;BUT and Δ;BTS in %; *p≤0,05 ; **p≤0,01] Conclusion:90 minutes after single dose application of all tested ophthalmic solutions the BUT was significantly reduced, but it was more disturbed after AC and CDT. BR diminished basal tear secretion at al points of follow up. However, BTS was also significantly decreased 60 and 90 minutes after AC and NaCl instillation. Surprisingly there was no significant change of BTS in CDT treated eyes. The results of this study might be helpful in finding the suitable therapy with regard to the individual tear film situation of glaucoma patients.
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