December 2002
Volume 43, Issue 13
ARVO Annual Meeting Abstract  |   December 2002
Pathologic Findings in the Cornea after Successful LASIK Surgery
Author Affiliations & Notes
  • TR Kramer
    Department of Ophthalmology Emory Eye Center Atlanta GA
  • HF Edelhauser
    Atlanta GA
  • HE Grossniklaus
    Atlanta GA
  • Footnotes
    Commercial Relationships   T.R. Kramer, None; H.F. Edelhauser , None; H.E. Grossniklaus , None. Grant Identification: NIHEY06360, NIHEY00933, RPB Inc
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 1094. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      TR Kramer, HF Edelhauser, HE Grossniklaus; Pathologic Findings in the Cornea after Successful LASIK Surgery . Invest. Ophthalmol. Vis. Sci. 2002;43(13):1094.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Abstract: : Purpose:To study pathologic changes in human corneas after successful LASIK surgery.Methods:Thirteen corneas were obtained post-mortem from seven patients had undergone successful LASIK surgery. The corneas were trisected and 1/3 of each cornea was routinely processed for histologic examination with hematoxylin/eosin and PAS staining, transmission electron microscopy with a JEOL 100CX TEM, and scanning electron microscopy of the wound interface with a JEOL 35CF SEM, respectively.Results:Corneas from four men and 3 women were examined at post-mortem intervals ranging from 3 to 36 months. The best-corrected visions of the patients were 20/15-20/20. The thickness of the LASIK flap ranged from 100-160um. There were reactive keratocytes at the wound interface, minor epithelial ingrowth in the superficial wound and PAS+/electron-dense material at the wound interface in 13, 7 and 4 corneas, respectively. TEM showed collagen fiber disorganization with deposition of an amorphous ground substance in both the flap and the bed.The wound interface appeared to stabilize at approximately 2 years post-LASIK. The deep stroma, Descemet’s membrane and endothelium appeared normal in all corneas.Conclusion:: Wound interface changes are present up to 36 months after successful LASIK. These changes appear to stabilize at approximately 2 years after LASIK.

Keywords: 454 laser • 507 pathology: human • 548 refractive surgery: LASIK 

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.