Purchase this article with an account.
SA Schellini, SR Bernardes, MA E Marques, CR Padovani, R Rossa; Gelatinous Polyethylene For Soft Tissue Augmentation- An Experimental Study In Rats . Invest. Ophthalmol. Vis. Sci. 2002;43(13):1101.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
Purpose:There is a great interest in synthetic materials to augment soft tissues because these substances are readily available avoiding problems related to their obtention and preservation. The purpose of this study was to evaluate the gelatinous polyethylene (GP) as a material to be used in soft tissue augmentation and the host response elicited by this substance in an animal model. Methods:GP was injected in the dorsal midline subcutaneous tissue of 24 rats. Three animals were sacrificed at 7(G1), 15 (G2), 30 (G3), 45(G4), 60(G5), 90(G6), 180(G7) and 365(G8) days after the GP injection. The material was removed and assessed to morphometric and histopathological evaluation. The results were statistically analised. Results:The GP persisted in the same infiltration area and the morphometric evaluation showed the GP volume maintenance during all experimental moments. Light microscopy showed minimal host response with few inflammatory cells at G1 and G2 and a dense fibrous formation after G3 surrounded by a thin pseudocapsule. Neither necrosis nor extrusion occurred in the skin overlying the GP. Conclusion:: The GP demonstrated to be a good material for soft tissue augmentation as it elicited minimal inflammation, persisted in the infiltration area and maintained the initial injected volume.
This PDF is available to Subscribers Only