December 2002
Volume 43, Issue 13
ARVO Annual Meeting Abstract  |   December 2002
Clinicopathologic Correlation of Margins of Resection of Uveal Melanoma
Author Affiliations & Notes
  • TM Aaberg
    Ophthalmology Associated Retinal Consultants and Spectrum Health Grand Rapids MI
  • BD Sippy
    Ophthalmology Emory University Atlanta GA
  • TM Aaberg Sr
    Ophthalmology Emory University Atlanta GA
  • HE Grossniklaus
    Ophthalmology Emory University Atlanta GA
  • Footnotes
    Commercial Relationships   T.M. Aaberg, None; B.D. Sippy, None; T.M. Aaberg Sr, None; H.E. Grossniklaus, None. Grant Identification: NIH Core Grant (P30 EY06360), RPB, Inc, and the RPB-AOS-Knapp Ophthalmic Pathology Fellowship
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 1131. doi:
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      TM Aaberg, BD Sippy, TM Aaberg Sr, HE Grossniklaus; Clinicopathologic Correlation of Margins of Resection of Uveal Melanoma . Invest. Ophthalmol. Vis. Sci. 2002;43(13):1131.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract: : Purpose:To evaluate the clinical and histopathologic features of two cases of surgically resected ciliochoroidal melanomas. Methods:Clinical features of two patients with ciliochoroidal melanoma were reviewed. The resection specimens were processed routinely for histologic examination with the anterior, posterior, deep and lateral margins of resection evaluated for the presence of melanoma. Subsequent enucleation specimens were processed and evaluated for the presence of melanoma. Results:In the first case, the tumor microscopically extended to the anterior and lateral margins of resection. The blind, painful eye was enucleated and failed to exhibit melanoma. In the second case, the melanoma was transected and the posterior margin was frankly positive for melanoma. The eye was enucleated for residual tumor, and a 3 x 2 nodule of melanoma was present. Conclusion:There are two types of positive surgical margins of excision for uveal melanoma; microscopic and transected tumor. Observation with or without local adjuvant therapy is recommended for the former, and local adjuvant therapy or enucleation is recommended for the latter.

Keywords: 464 melanoma • 507 pathology: human • 628 vitreoretinal surgery 

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