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H Demirci, CL Shields, JA Shields, SG Honavar, RC Eagle Jr; Diffuse Iris Melanoma: A report of 25 cases . Invest. Ophthalmol. Vis. Sci. 2002;43(13):1144.
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Purpose: To report the clinical characteristics, management, and outcome of diffuse iris melanoma. Methods: A retrospective review of 25 consecutive patients. Results: The mean patient age was 49 years. The initial complaint was unilateral darker eye color (52%) and blurred vision (24%). The most common initial diagnosis by referring physician was unilateral glaucoma (56%) and the mean intraocular pressure at referral was 36 mmHg. The most common clinical findings included heterochromia iridis (100%), corectopia (92%) and ectropion irides (84%). Management was enucleation (88%) and plaque brachytherapy (12%). The most common cell type was mixed cell (68%). Liver metastasis developed in 13% at a mean follow-up of 78 months (range 4 to 210 months). Conclusion: Diffuse iris melanoma is a serious condition that causes unilateral hyperchromic heterochromia and secondary glaucoma. Distant metastasis occurs in 13% at mean 6 years follow-up.
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