December 2002
Volume 43, Issue 13
Free
ARVO Annual Meeting Abstract  |   December 2002
Prospective Case-Control Study of Infrared Fundus Imaging in Subjects at High and Low Genetic Risk for AMD
SN Appa; AN Safar; W Anderson; AO Edwards
Author Affiliations & Notes
  • SN Appa
    Ophthalmology University of Texas Southwestern Medical Center Dallas TX
  • AN Safar
    Ophthalmology University of Arkansas Little Rock AR
  • W Anderson
    Ophthalmology University of Texas Southwestern Medical Center Dallas TX
  • AO Edwards
    Ophthalmology University of Texas Southwestern Medical Center Dallas TX
  • Footnotes
    Commercial Relationships   S.N. Appa, None; A.N. Safar, None; W. Anderson, None; A.O. Edwards, None. Grant Identification: Support: Research to Prevent Blindness
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 1206. doi:
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      SN Appa, AN Safar, W Anderson, AO Edwards; Prospective Case-Control Study of Infrared Fundus Imaging in Subjects at High and Low Genetic Risk for AMD . Invest. Ophthalmol. Vis. Sci. 2002;43(13):1206.

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Abstract

Abstract: : Purpose: To determine the type and frequency of infrared (IR) reflectance abnormalities in subjects with high and low genetic risk for AMD. Methods: Stereoscopic color and IR fundus imaging were prospectively performed on 23 descendents of patients with AMD and an affected first-degree relative and 19 subjects without a family history of AMD. All subjects were between age 40 to 55 years. Results: Drusen and IR reflectance abnormalities were frequent in both groups, but more common in high-risk subjects. Ten subjects (43.5%) in the high-risk group compared to one (5.3%) in the control group had greater than 20 infrared reflectance abnormalities (p<0.03). Conclusion: Infrared imaging may be useful in identifying young individuals at risk for developing AMD.

Keywords: 308 age-related macular degeneration • 430 imaging/image analysis: clinical • 391 drusen 
© 2002, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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