December 2002
Volume 43, Issue 13
ARVO Annual Meeting Abstract  |   December 2002
A Rabbit Model To Study Orbital Venous Pressure, Intraocular Pressure And Ocular Hemodynamics Simultaneously
Author Affiliations & Notes
  • HA Reitsamer
    Dept of Physiology Univ Vienna Med School Vienna Austria
  • JW Kiel
    Dept of Ophthalmology Univ Texas Health Sci Ctr San Antonio TX
  • Footnotes
    Commercial Relationships   H.A. Reitsamer, None; J.W. Kiel, None. Grant Identification: NIH Grant EY09702, Austrian Grant FWF1866-MED
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 839. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      HA Reitsamer, JW Kiel; A Rabbit Model To Study Orbital Venous Pressure, Intraocular Pressure And Ocular Hemodynamics Simultaneously . Invest. Ophthalmol. Vis. Sci. 2002;43(13):839.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Abstract: : Purpose: To measure orbital venous pressure (OVP) and determine the effects of changes in mean arterial pressure (MAP) on OVP, intraocular pressure (IOP), episcleral venous pressure (EVP) and ciliary and choroidal blood flows. Methods: The experiments were performed in anesthetized rabbits. In all animals, MAP, IOP and OVP were measured by direct cannulation of the central ear artery, the vitreous, and the orbital venous sinus, respectively. Laser Doppler flowmetry was used to measure choroidal blood flow in one group, and ciliary blood flow in a second group. A servonull micropressure system was used to measure EVP in a third group. The protocol for all 3 groups entailed varying MAP mechanically with occluders on the abdominal aorta and the vena cava inferior.  

Results: The OVP and IOP relationship was linearly correlated (r = 0.996) during mechanical manipulation of MAP. EVP also correlated well with OVP and IOP (r ≷ 0.8). Resistance calculations based on choroidal and ciliary blood flows and the pressure gradients indicate active adjustment of arterial resistance and passive changes of venous resistance in response to changing MAP. Conclusion: The rabbit orbital venous sinus permits continuous measurements of OVP. The present findings show the importance of OVP in IOP homeostasis and its involvement in ocular hemodynamics.

Keywords: 316 animal model • 444 intraocular pressure • 331 blood supply 

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.