December 2002
Volume 43, Issue 13
Free
ARVO Annual Meeting Abstract  |   December 2002
Incidence of Nuclear Lens Opacities and Related Factors in the Barbados Eye Studies
Author Affiliations & Notes
  • M Leske
    School of Medicine Stony Brook University Stony Brook NY
  • SY Wu
    School of Medicine Stony Brook University Stony Brook NY
  • B Nemesure
    School of Medicine Stony Brook University Stony Brook NY
  • A HennisBarbados Eye Studies Group
    Ministry of Health and University of the West Indies Bridgetown Barbados
  • Footnotes
    Commercial Relationships   M. Leske, None; S.Y. Wu, None; B. Nemesure, None; A. Hennis, None. Grant Identification: NEI grants #EY07625 and #EY07617
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 934. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      M Leske, SY Wu, B Nemesure, A HennisBarbados Eye Studies Group; Incidence of Nuclear Lens Opacities and Related Factors in the Barbados Eye Studies . Invest. Ophthalmol. Vis. Sci. 2002;43(13):934.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Abstract: : Purpose: To present risk factors for the 4-year incidence of nuclear opacities in black participants of the Barbados Eye Studies cohort (85% participation). Methods: The standardized protocol included various measurements, an interview, slit-lamp lens gradings, fundus photography, and an ophthalmologic examination. Associations with the incidence of nuclear opacities (LOCS II N2) were evaluated by logistic regression among 2609 persons without nuclear opacities at baseline. Results: The 4-year incidence was 9.2% (241/2609), increasing markedly with age. Risk factors included female gender (RR=1.8), darker iris color (RR=4.9), myopia (RR=2.8), diabetes history (RR=1.6), leaner body mass (RR=0.95), and treatment to lower the intraocular pressure (IOP) (RR=2.7), mainly topical beta-blockers. The 59 treated participants had a 3-fold RR of nuclear opacities (RR=3.2; (95% confidence interval: 1.6, 6.6)), as compared to those untreated and with IOP ≤21mmHg. For the subset of participants with IOP≷21mmHg, the risk was 5-fold (RR=5.0 (1.7,15.1)) among those receiving treatment (n=33) vs. those untreated. Risks were also higher for treated persons with open-angle glaucoma. Conclusions: The 4-year risk of nuclear opacities increased with age, female gender, darker iris color, myopia, diabetes, and leaner body mass, indicating similarities with other populations. Use of topical IOP-lowering medications was related to an increased RR of nuclear opacities in this study, a result to be verified in clinical trials evaluating such treatment.

Keywords: 355 clinical (human) or epidemiologic studies: risk factor assessment • 354 clinical (human) or epidemiologic studies: prevalence/incidence • 338 cataract 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×