December 2002
Volume 43, Issue 13
Free
ARVO Annual Meeting Abstract  |   December 2002
Activin A and VEGF are Coregulated in Choriodal Neovascular Membranes
LM Le; V Poulaki; A Lappas; B Kirchhof; AM Joussen
Author Affiliations & Notes
  • LM Le
    Vitreoretinal Surgery Center for Ophthalmology University of Cologne Cologne Germany
  • V Poulaki
    Massachusetts Eye and Ear Infirmary Harvard Medical School Boston MA
  • A Lappas
    Massachusetts Eye and Ear Infirmary Harvard Medical School Boston MA
  • B Kirchhof
    Vitreoretinal Surgery Center for Ophthalmology University of Cologne Cologne Germany
  • AM Joussen
    Vitreoretinal Surgery Center for Ophthalmology University of Cologne Cologne Germany
  • Footnotes
    Commercial Relationships   L.M. Le, None; V. Poulaki, None; A. Lappas, None; B. Kirchhof, None; A.M. Joussen, None.
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 1302. doi:
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      LM Le, V Poulaki, A Lappas, B Kirchhof, AM Joussen; Activin A and VEGF are Coregulated in Choriodal Neovascular Membranes . Invest. Ophthalmol. Vis. Sci. 2002;43(13):1302.

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Abstract

Abstract: : Purpose:Activin A is a dimeric glycoprotein that belongs to the transforming growth factor beta (TGF-beta) superfamily and is involved in the pathogenesis of proliferative membrane formation in both ischemic and nonischemic vitreoretinal diseases. We examined the protein levels and localization of activin A and VEGF in epiretinal and preretinal neovascular membranes. Methods:In 36 Patients with age related macular degeneration, CNV were excised by pars plana-vitrectomy. Membranes were snap frozen in liquid nitrogen or processed for embedding in paraffin. Activin A and VEGF choroidal protein levels were measured with an ELISA assay. Tissue sections were stained for CD31, VEGF and Activin A. Results:The total protein levels of activin A in the membranes correlated with the total VEGF protein levels. CD31 positive vascular endothelial cells as well as RPE cells were positive for VEGF and activin A with immunohistochemistry. The fibrotic areas of the vascular membranes were negative for activin A and VEGF. Conclusion:: Activin A is a potential autocrine and/or paracrine regulator of the VEGF expression in RPE and endothelial cells. Given the established role of VEGF in the formation of the CNV membranes, we can conclude that activin A plays a role in the pathogenesis of choroidal neovascularization by regulating the expression of VEGF.

Keywords: 346 choroid: neovascularization • 423 growth factors/growth factor receptors • 483 neovascularization 
© 2002, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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