December 2002
Volume 43, Issue 13
ARVO Annual Meeting Abstract  |   December 2002
Identification of Dog VKH Disease and Experimental Model of VKH in Dog
Author Affiliations & Notes
  • K Hayakawa
    Ophthalmology Akita Universtiy School of Medicine Akita Japan
  • K Yamaki
    Ophthalmology Akita Universtiy School of Medicine Akita Japan
  • N Takiyama
    Ophthalmology Rakunou Gakuen University Akita Japan
  • T Kotani
    Ophthalmology Rakunou Gakuen University Akita Japan
  • N Itoh
    Ophthalmology Yokohama City College Akita Japan
  • Footnotes
    Commercial Relationships   K. Hayakawa, None; K. Yamaki, None; N. Takiyama, None; T. Kotani, None; N. Itoh, None.
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 1569. doi:
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      K Hayakawa, K Yamaki, N Takiyama, T Kotani, N Itoh; Identification of Dog VKH Disease and Experimental Model of VKH in Dog . Invest. Ophthalmol. Vis. Sci. 2002;43(13):1569.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract: : Purpose:Identification of clinical features of the disease highly resembles to human Vogt-Koyanagi-Harada disease(VKH) in Akita dog and establishment of the autoimmune disease resembles to human VKH disease(dog VKH) in Akita dog. Methods:The clinical features of 4 cases of dog VKH in Akita dogs treated in the hospital of Veterinary medicine, Rakunou Gakuen University were investigated retrospectively. Two of the normal healthy Akita dogs were immunized with the peptides derived from tyrosinase related protein 1(TRP1). The clinical examination was done with slit lamp biomicroscopy and fundus scope. Fluorescein fundus angiography was also done. Results:All the dog suffering dog VKH had pan uveitis and multiple exudative retinal detachment in both eyes. Depigmentation of the skin and/or eyelid skin were seen in all the dogs in convalescent stage. Hair loss was also observed in all the dogs. Sunset glow funfus like changes were also observed in late stage of the disease. All the dogs immunized with TRP1 developed pan uveitis in both eyes. Inflammatory cells infiltrated into anterior and posterior chamber and vitreous. Multiple exudative retinal detachment were seen in both eyes. Conclusion:The dog VKH disease in Akita dogs were thought to be identical to human VKH from the clinical features. The autoimmune disease induced by the immunization of TRP1 peptides in Akita dogs was almost identical to human VKH like disease in Akita dogs.

Keywords: 612 uveitis-clinical/animal model • 327 autoimmune disease • 463 melanocytes 

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