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AM Renucci, AC Romano, SH Yoo, M Muallem, WW Culbertson; Correlation Between Central Corneal Thickness And Intraocular Pressure In Normal Subjects . Invest. Ophthalmol. Vis. Sci. 2002;43(13):1718.
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Purpose: To investigate the relationship between intraocular pressure (IOP) and central corneal thickness (CCT) in normal subjects. Methods: Sixty-five right eyes of sixty-five normal human subjects had their IOP measurements taken with the Tono-Pen in the central cornea. Central corneal thickness (CCT) was evaluated using the Orbscan II and ultrasound (US) pachymeter devices. All measurements were obtained in patients undergoing preoperative refractive surgery evaluations. The correlation between changes in IOP and corneal thickness was evaluated by regression analysis. Results: The mean US CCT was 545 microns (S.D.=+/- 30; range=472-609). The mean Orbscan II CCT was 552 microns (S.D.= +/- 39; range=474-641). The correlation of Orbscan II CCT measurements and IOP was significant (p = 0.019, r = 0.29). The correlation between US CCT and IOP was of borderline significance (p = 0.07, r = 0.23). There was a highly significant correlation between Orbscan II CCT and US CCT, but not strong enough to suggest that the measurements are interchangeable (p < 0.001, r = 0.71). The difference between the Orbscan II and US CCT did not depend on IOP (r = 0.16, p = 0.21). Conclusion: In this study group of normal subjects, a significant, but weak correlation was found between central corneal thickness and intra-ocular pressure.
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