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D Armstrong, A Higa, S Iwabuchi, M Wood; Vascular Targeting Activity of Combretastatin A-4 Phosphate (CA4P) in an Ocular Model of Angiogenesis . Invest. Ophthalmol. Vis. Sci. 2002;43(13):1752.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose:To investigate CA4P’s vascular targeting activity on corneal neovascularization (NV) in rabbits. Methods:Neovascularization was induced in rabbit corneas by injecting 60 mg of linoleic acid hydroperoxide (LHP) into the superior quadrant stromas. Rabbits (n=5) received CA4P-treatment (50 mg/kg, IP, qd x 5) three days after induction of NV. A second group (n=7) received CA4P-treatment 10-days after NV induction. Results: CA4P-treatment after 3-days of growth completely inhibited NV (p < 0.001) and CA4P-treatment after 10-days inhibited or slightly regressed the NV (p < 0.01). Conclusion: Systemic CA4P treatment inhibits the growth proliferating blood vessels in the cornea and damages established corneal NV.
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