December 2002
Volume 43, Issue 13
Free
ARVO Annual Meeting Abstract  |   December 2002
Vascular Targeting Activity of Combretastatin A-4 Phosphate (CA4P) in an Ocular Model of Angiogenesis
Author Affiliations & Notes
  • D Armstrong
    Small Animal Clinical Sci Univ of Florida College of Veterinary Med Gainesville FL
  • A Higa
    Department of Ophthalmology Showa University School of Medicine Tokyo Japan
  • S Iwabuchi
    Department of Ophthalmology Showa University School of Medicine Tokyo Japan
  • M Wood
    Drug Development OXiGENE Inc Watertown MA
  • Footnotes
    Commercial Relationships    D. Armstrong, OXiGENE, Inc. F; A. Higa, OXiGENE, Inc. F; S. Iwabuchi, OXiGENE, Inc. F; M. Wood, OXiGENE, Inc. E.
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 1752. doi:
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    • Get Citation

      D Armstrong, A Higa, S Iwabuchi, M Wood; Vascular Targeting Activity of Combretastatin A-4 Phosphate (CA4P) in an Ocular Model of Angiogenesis . Invest. Ophthalmol. Vis. Sci. 2002;43(13):1752.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose:To investigate CA4P’s vascular targeting activity on corneal neovascularization (NV) in rabbits. Methods:Neovascularization was induced in rabbit corneas by injecting 60 mg of linoleic acid hydroperoxide (LHP) into the superior quadrant stromas. Rabbits (n=5) received CA4P-treatment (50 mg/kg, IP, qd x 5) three days after induction of NV. A second group (n=7) received CA4P-treatment 10-days after NV induction. Results: CA4P-treatment after 3-days of growth completely inhibited NV (p < 0.001) and CA4P-treatment after 10-days inhibited or slightly regressed the NV (p < 0.01). Conclusion: Systemic CA4P treatment inhibits the growth proliferating blood vessels in the cornea and damages established corneal NV.

Keywords: 483 neovascularization • 372 cornea: epithelium • 316 animal model 
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