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MJ Jager, CJ M Krose, W Zuidervaart, P Eilers, SR Boyd, G Van der Pluijm, JE E Keunen, D De Wolff-Rouendaal, HM H Hurks; Vascular Endothelial Growth Factor (VEGF) In Aqueous Humor: Prognostic Factor In Uveal Melanoma . Invest. Ophthalmol. Vis. Sci. 2002;43(13):1829.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To investigate the prognostic significance of the vascular endothelial growth factor (VEGF) level in aqueous humor of uveal melanoma patients. VEGF is an important stimulator of tumor angiogenesis. Methods: VEGF concentrations were determined in aqueous humor samples of 74 uveal melanoma patients using a commercial ELISA kit obtained from Biosource. Aqueous humor was collected immediately after enucleation and stored at -80 °C until use. The results were compared to patient survival and clinical and histopathological tumor parameters. Follow-up time was 1 to 9 years. Results: The VEGF concentration in aqueous humor varied substantially, ranging from <4 to 1979 pg/ml with a mean concentration of 192 pg/ml. High VEGF concentration was significantly correlated with a large tumor diameter (p<0.005) and prominence (p<0.001) and seemed to be associated with the presence of epithelial cells within the tumor (p<0.07). VEGF level also was significantly correlated with patient survival (Cox Proportional Hazard p<0.026). Conclusion:The concentration of VEGF in the aqueous humor was significantly correlated with patient survival and therefore can be regarded as a prognostic factor in human uveal melanoma.
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