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DW Evans, J Bartlett, B Houde, T Than; Effect of Latanoprost Therapy on Contrast Sensitivity in Glaucoma Patients . Invest. Ophthalmol. Vis. Sci. 2002;43(13):2129.
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Purpose: Previous studies have demonstrated that visual function as measured by contrast sensitivity (CS) improves in primary open-angle glaucoma (POAG) patients following ocular hypotensive therapy. Some data suggests that certain treatments may provide improved visual function despite no or only a small change in IOP. The purpose of this study was to prospectively compare the effects of latanoprost and timolol maleate in Gelrite on CS. Methods: Twenty POAG patients on a monotherapy treatment regimen of topical beta blockade and with clinically stable IOP were recruited for this single-masked, randomized, crossover study. Subjects were randomized to begin treatment with latanoprost 0.005% once daily in the evening or timolol maleate 0.5% in Gelrite once daily in the morning. At the end of a 3-month treatment period, each subject was crossed-over to receive the alternative treatment for three months. Blood pressure, heart rate, IOP, and CS (CSV-1000E, VectorVision) were assessed at baseline and after 4, 12, 16, and 24 weeks of treatment. CS was evaluated at four spatial frequencies, 3, 6, 12, and 18 cycles/degree. Visual field sensitivity was evaluated using the Humphrey 24-2 Fastpac program at baseline and after 12 and 24 weeks of treatment. Results: Subjects who were treated for three months with latanoprost, after being switched from timolol, experienced an improvement in CS at 3 cpd (p=0.03). Conversely, subjects who were treated for three months with timolol, after being switched from latanaprost, demonstrated a significant loss in CS at 3 cpd (p=0.04) and at 18 cpd (p=0.03). Neither group demonstrated a change in IOP or visual field sensitivity. Conclusion: Compared with timolol maleate in Gelrite, latanoprost appears to significantly improve central visual function as measured by contrast sensitivity.
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