December 2002
Volume 43, Issue 13
ARVO Annual Meeting Abstract  |   December 2002
Pointwise Linear Regression of Visual Fields Over Extended Follow Up
Author Affiliations & Notes
  • MR Wilkins
    Glaucoma Unit Moorfields Eye Hospital London United Kingdom
  • PT Khaw
    Wound Healing Research Unit
    Institute of Ophthalmology London United Kingdom
  • FW Fitzke
    Dept of Visual Science
    Institute of Ophthalmology London United Kingdom
  • Footnotes
    Commercial Relationships   M.R. Wilkins, None; P.T. Khaw, None; F.W. Fitzke, None. Grant Identification: MRC(UK) grant G9330070
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 2149. doi:
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    • Get Citation

      MR Wilkins, PT Khaw, FW Fitzke; Pointwise Linear Regression of Visual Fields Over Extended Follow Up . Invest. Ophthalmol. Vis. Sci. 2002;43(13):2149.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract: : Purpose:We previously demonstrated at ARVO the effects thatpointwise linear regression (PLR) criteria had on detectionof change in a visual field series. Here we use validated criteriato measure change over a longer field series.Methods:Visualfields from 127 patients, undergoing trabeculectomy, and followedfor 40 months were analysed using PLR. Change was assessed over6, 8, 10, or 12 fields, and over the first and last 6 fields.The criterion for change was 2 points changing in a perimetricnerve fibre bundle cluster with significance ranging from P<0.001to 0.05 and a slope= 1dB/yr.Results:Mean deviation at surgerywas -9.9dB and mean duration from diagnosis to surgery was 55months. At all significance levels, detection of progressionwas greater than improvement and increased at a greater ratewith increased follow up (table 1). Table 1  

Analysis over the firstand second 6 fields detected similar levels of improvement.Numbers of eyes showing progression were higher over the first6 fields.Progression and improvement occurred at similar levelsover the second 6 fields (Table 2).Table 2 Conclusion:Following trabeculectomy visual field progression was greaterthan improvement and increased at a greater rate than improvementwith time. However much of this difference is attributable toearly change over the first 6 months. If change occurs later,different methods will be required to assess it.

Keywords: 624 visual fields • 359 clinical research methodology 

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