December 2002
Volume 43, Issue 13
ARVO Annual Meeting Abstract  |   December 2002
Leukocyte Adhesion Molecules in Ocular Rosacea
Author Affiliations & Notes
  • P Zafirakis
    Ophthalmology Zafirakis Eye Center Athens Greece
  • A Voudouri
    Ophthalmology Athens Ophthalmic Center Athens Greece
  • G Livir-Rallatos
    Ophthalmology Athens Ophthalmic Center Athens Greece
  • C Livir-Rallatos
    Ophthalmology Tulane University New Orleans LA
  • C Canakis
    Ophthalmology Tulane University New Orleans LA
  • N Markomichelakis
    Ophthalmology General Hospital of Athens Athens Greece
  • S Baltatzis
    Ophthalmology Athens Medical School Athens Greece
  • Footnotes
    Commercial Relationships   P. Zafirakis, None; A. Voudouri, None; G. Livir-Rallatos, None; C. Livir-Rallatos, None; C. Canakis, None; N. Markomichelakis, None; S. Baltatzis, None.
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 2225. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      P Zafirakis, A Voudouri, G Livir-Rallatos, C Livir-Rallatos, C Canakis, N Markomichelakis, S Baltatzis; Leukocyte Adhesion Molecules in Ocular Rosacea . Invest. Ophthalmol. Vis. Sci. 2002;43(13):2225.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Abstract: : Purpose: To analyze the expression and cellular distribution of leukocyte adhesion molecules in ocular rosacea, and to elucidate any difference in expression of adhesion molecules in diseased and in normal human conjunctiva. Methods: A panel of monoclonal antibodies against to VCAM-1, VLA-4, ICAM-1, LFA-1, and E-Selectin were utilized to perform immunochistochemical staining on frozen sections cryo-preserved human conjunctiva. Conjunctival biopsy specimens were obtained from 15 patients with rosacea and from 15 healthy individuals undergoing cataract surgery. Results: The expression of LFA-1 and its ligand ICAM-1 was significantly higher on connective tissue cells within the substantial propria in rosacea patients compared to healthy individuals. ICAM-1 expression was present on the vascular endothelium in most patients. VCAM-1 expression was significantly up-regulated in rosacea patients in comparison to normals and showed a perivascular cellular distribution. Expression of VLA-4 and E-Selectin was noted only in rosacea patients. Conclusions: The simultaneous and continued over-expression of the studied adhesion molecules in rosacea patients suggests that their interaction may contribute to a sustained immune response as at least part of the pathologic mechanism of this disorder.

Keywords: 366 conjunctivitis • 339 cell adhesions/cell junctions • 434 immunohistochemistry 

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.