December 2002
Volume 43, Issue 13
Free
ARVO Annual Meeting Abstract  |   December 2002
Long Term Survival of Corneal Grafts Preserved in McCarey-Kaufman (M-K) Medium Compared to Mimimal Essential Medium (MEM) in Patients With Keratoconus
Author Affiliations & Notes
  • NE M L Tang
    Ophthalmology Eye Hospital Rotterdam Rotterdam Netherlands
  • L Oktem
    Ophthalmology The Rotterdam Eye Hospital Rotterdam Netherlands
  • G van Rij
    Ophthalmology Erasmus University Rotterdam Rotterdam Netherlands
  • WJ Rijneveld
    Ophthalmology Westfries Gasthuis Hoorn Netherlands
  • L Remeijer
    Ophthalmology The Rotterdam Eye Hospital Rotterdam Netherlands
  • WH Beekhuis
    Ophthalmology The Rotterdam Eye Hospital Rotterdam Netherlands
  • Footnotes
    Commercial Relationships   N.E.M.L. Tang, None; L. Oktem, None; G. van Rij, None; W.J. Rijneveld, None; L. Remeijer, None; W.H. Beekhuis, None. Grant Identification: Support: The Rotterdam Eye Hospital Research Found
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 2239. doi:
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      NE M L Tang, L Oktem, G van Rij, WJ Rijneveld, L Remeijer, WH Beekhuis; Long Term Survival of Corneal Grafts Preserved in McCarey-Kaufman (M-K) Medium Compared to Mimimal Essential Medium (MEM) in Patients With Keratoconus . Invest. Ophthalmol. Vis. Sci. 2002;43(13):2239.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To compare the functionality of corneal grafts preserved in two different media(M-K medium at 4ºC and MEM at 31ºC) in patients undergoing penetrating keratoplasty for keratoconus) after a follow-up period of 14 years. Methods: Eighteen paired human corneas, preserved in M-K medium and in MEM, were transplanted in patients with keratoconus between 1986 and 1988. After a follow-up period of 14 years, visual acuity, central corneal thickness, and endothelial cell density were assessed and compared in both groups. These recent measurements were also compared to the 1- to 2- year follow-up data I. Wilcoxon matched-pairs signed-rank test was used for statistical analysis Results: Mean follow-up period was 166 7.7 months. No allograft reactions were documented.  

Conclusions: Except corneal thickness, no significant differences were found between grafts preserved in M-K medium compared to MEM. Osmotic changes related to dextran, added to MEM, is probably the cause of the difference in corneal thickness between the groups. We assessed a high ongoing endothelial cell loss of 6 % per year throughout the observation period, which was higher than the physiological endothelial loss in normal corneas (0.6 % per year).II I Arch Ophthalmol.1992;110:203-205 II Cornea 2001;20(6):560-569<br

Keywords: 369 cornea: clinical science • 371 cornea: endothelium • 353 clinical (human) or epidemiologic studies: outcomes/complications 
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