December 2002
Volume 43, Issue 13
ARVO Annual Meeting Abstract  |   December 2002
Pigmentary Retinopathy Associated with Intravitreal Fomivirsen
Author Affiliations & Notes
  • SH Uwaydat
    Ophthalmology & Visual Sciences University of Texas Medical Branch Galveston TX
  • HK Li
    Ophthalmology & Visual Sciences University of Texas Medical Branch Galveston TX
  • Footnotes
    Commercial Relationships   S.H. Uwaydat, None; H.K. Li, None. Grant Identification: Research to Prevent Blindness,
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 2245. doi:
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      SH Uwaydat, HK Li; Pigmentary Retinopathy Associated with Intravitreal Fomivirsen . Invest. Ophthalmol. Vis. Sci. 2002;43(13):2245.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract: : Purpose: This study reports retinal and electroretinographic changes in eyes receiving intravitreal fomivirsen for cytomegalovirus retinitis. Methods: We observed two eyes with retinal pigmentary and electroretinographic abnormalities after intravitreal fomivirsen. We also reviewed records of all patients who received intravitreal fomivirsen. Results: Thirty-four injections were administered in ten eyes of nine patients (range: 1 to 23 injections per eye). Two eyes of two patients who failed highly active antiretroviral therapy developed retinal pigment changes in the mid peripheral retina associated with absent rod response and 40-50% reduction in cone amplitude. The first patient received only 1 injection. The second patient received a total of 5 injections. Conclusion: Eyes treated with approved dosage regimen of intravitreal fomivirsen developed retinal toxicity. This study’s findings support the premise that intravitreal fomivirsen may have a narrow therapeutic index.

Keywords: 382 cytomegalovirus • 390 drug toxicity/drug effects • 353 clinical (human) or epidemiologic studies: outcomes/complications 

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