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T Ariga, K Aoki, T Ohashi, S Kotake, E Uchio, Y Tagawa, S Ohno; The Molecular Epidemiology of Adenovirus Keratoconjunctivitis in Sapporo, Japan 1978-2000 . Invest. Ophthalmol. Vis. Sci. 2002;43(13):2250.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To elucidate the virus serotype and genometype of adenovirus(Ad) keratoconjunctivitis in the past 23 years(1978-2000) in a Eye clinic in sapporo, Japan. Methods: Total of 1515 cases with Ad keratoconjunctivitis were examined by virus isolation and polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) methods to detect Ad serotype and genometype. Results: 1) The incidence of Ad serotype was Ad3 18.2%, Ad4 27.3%, Ad8 23.7%, Ad19 10.9%, Ad37 17.6%. Ad7,11,34 and 35 were also detected in small number. The incidence of Ad8 and Ad4 decreased in number in the recent years. 2) The most predominant serotypes of Ad changed almost in every year and each serotype of Ad such as Ad8, Ad3 and Ad4 appeared to be epidemic periodically in almost every three or four years. 3) In the observed periods genometype conversions were found in Ad3(f,g→h/h,i), Ad8(a,b→b,e), Ad19(a→a,b), and Ad37(p→p,a→p,a,b→p,a,b,c). However, Ad4 and Ad11 showed no genometype conversions. Conclusion: It is concluded that subgenous D of adenovirus was predominant viruses causing Ad keratoconjunctivitis in the past 23 years. It is possible that genome type conversions have some relations with the epidemic occurrence of Ad keratoconjunctivitis.
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