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X Li, J Chen; The Vitreous Degenerative Changes in High Myopia . Invest. Ophthalmol. Vis. Sci. 2002;43(13):2451.
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Purpose: We studied the biochemical changes in high myopic vitreous to understand the vitreous degeneration and the reason why high myopic eyes are vulnerable to retinal detachment. Methods: The quantitative measure of protein, sodium dodecyl sulfate polyacrylamide gel electrophoresis(SDS/PAGE), Western Blot, uronic acid carbozole reaction were used to analyze soluble protein, hyaluronic acid and transferrin in the vitreous of 21 vitrectomy eyes of patients over 40 years old. Results: There is a positive correlation between protein and refraction (r=0.3308,p=0.006). The concentration of HA is lower (p=0.022) while that of transferrin is higher in high myopia (p≷0.05). Conclusion: Our study indicates the breakdown of blood-vitreous barrier in high myopic eyes.
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