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R Sarrafizadeh, AS Noffke, GA Williams, RR Margherio, BR Garretson, A Capone Jr, AJ Ruby, TS Hassan, MT Trese; Factors Associated with Macular Hole Re-opening After Successful Closure . Invest. Ophthalmol. Vis. Sci. 2002;43(13):2492.
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Purpose: To evaluate factors associated with macular hole (MH) re-opening. Methods: Records of 472 patients who had MH surgery with a mean follow-up of 40 months (range 6-101) were reviewed. Incidence of hole re-opening and visual results were analyzed. Results: 448 of 501 holes closed after vitrectomy (89%). 49 (11%) of the closed holes re-opened on average in 8.9 months (range 3-57). Factors associated with hole re-opening were macular pucker with cystoid macular edema (CME) in 17 eyes (35%), retinal detachment in 6 eyes (12%), and CME following cataract surgery in 2 eyes (4%). Rate of hole closure following a second vitrectomy was 96%, with these eyes achieving similar final visual results (20/65) when compared to eyes with successful closure after a single operation (20/54, p=0.15). Conclusion: Many eyes that experience MH re-opening have associated CME. Repeat surgery is usually successful in closing recurrent holes.
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