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R Migliardi, A Harris, CJ Amin, L Kagemann, E Rechtman, AB Yee, C Jonescu-Cuypers; Test-Retest Reproducibility of a Spectrographic Digital Fundus Oxymeter . Invest. Ophthalmol. Vis. Sci. 2002;43(13):2563.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose:To determine the reproducibility of a newly developed spectrographic digital fundus oxymeter. Methods:Eighteen healthy subjects (27.2 4.92 years) were recruited for this study. Three measurements, focusing on the major temporal retinal vessels adjacent to the optic disc, were obtained while breathing room air. The fundus was illuminated by white light, of which two frequencies were quantified (605nm, oxygen sensitive and 586nm, oxygen insensitive). After calibrating the images to optical densities the optical density ratio (ODR) between oxygen sensitive and insensitive wavelengths was calculated. Baseline and hyperoxic ODR in the temporal arteries and veins were compared by Wilcoxon signed rank paired comparison (≤ 0.05 considered significant). Results:The coefficient of variation (CoV) was calculated for each measurement. The CoV of arterial ODR was 12% and venous ODR was 13%. Venous ODR was significantly lower than arterial ODR (p = 0.0427). Conclusion:By digitally quantifying isolated frequencies of light scattered from retinal arterial and venous blood, the newly developed oxymeter is capable of reproducible assessment of oxygen tension. With validation this technology may be useful for clinical assessment of ocular vascular conditions, such as diabetic retinopathy, age-related macular degeneration, and glaucoma.
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