December 2002
Volume 43, Issue 13
ARVO Annual Meeting Abstract  |   December 2002
Histological evaluation of Macular Pigment in the human retina
Author Affiliations & Notes
  • D Pauleikhoff
    Department of Ophthalmology St Franziskus Hospital Munster Germany
  • E van Kuijk
    Institute of Ophthalmology London United Kingdom
  • R Alexander
    Institute of Ophthalmology London United Kingdom
  • A Bird
    Institute of Ophthalmology London United Kingdom
  • P Luthert
    Institute of Ophthalmology London United Kingdom
  • Footnotes
    Commercial Relationships   D. Pauleikhoff, None; E. van Kuijk, None; R. Alexander, None; A. Bird, None; P. Luthert, None. Grant Identification: Pa 357/5-1
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 2564. doi:
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      D Pauleikhoff, E van Kuijk, R Alexander, A Bird, P Luthert; Histological evaluation of Macular Pigment in the human retina . Invest. Ophthalmol. Vis. Sci. 2002;43(13):2564.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract: : Purpose: Clinical investigations demonstrated a variation in the peak optical density as well as the spatial distribution of macular pigment. To confirm these results histologically the present study examined the distribution of macular in the human retina. Methods: The macular retina of 12 donor eyes of different ages were examined histologically on 100 µm vibratome sections directly with white light, without any staining. Photographs for documentation were taken immedeately from each section. Results: The macula demonstrated a variation in the spatial extension of the visible macular pigment between 400 - 900 µm diameter around the center of the fovea with no correlation with the donor age. The main location of macular pigment was in the layer of the fibres of Henle in the fovea and in between the nuclear layers in the parafovea. Conclusion: Histologically a wide variation of the spatial distribution could be observed which confirms psychophysical and clinical findings of motion photometry and autofluorescence images. Given the large variation in spatial extension, peak optical density of MP may not be appropriate to estimate MP content. The primary localisation of macular pigment is in the inner retinal layers of the fovea and parafovea.

Keywords: 462 macular pigment • 308 age-related macular degeneration • 337 carotenoids/carotenoid binding proteins 

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