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MW Wilson, DM Moshfeghi, WS Grizzard, BG Haik; Late Complications after Surgical Intervention in Monocular Patients with Quiescent Retinoblastoma . Invest. Ophthalmol. Vis. Sci. 2002;43(13):2600.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To describe the late complications following surgical intervention in six patients with quiescent retinoblastoma. Methods: A retrospective review was made of the records of all patients who had undergone intraocular surgery in any eye previously treated for retinblastoma. Reese-Ellsworth classification, ophthalmologic examination, final visual acuity at last follow-up, histopathologic evaluation (as appropriate), and length of follow-up were noted. Results: Six eyes of 6 patients were identified who met the criteria. Average age at diagnosis was 9.5 months (median 8 months). Five of six patients had one eye previously enucleated for retinoblastoma. The original Reese-Ellsworth classification for 3 eyes was unavailable. Of the remaining three eyes, one was a group II-b and two were group IV-b. The first intraocular surgery was either for a cataract (n=3) or a retinal detachment (n=3). Average time to first surgery was 88.3 months (median 90 months, range 12-172 months) after the last tumor treatment. Following the initial surgical intervention, a median of 2 additional surgeries (range 0-5) were performed. In three eyes, the tumor reactivated and enucleation was performed. Histopathologic examination demonstrated tumor in the anterior chamber of each enucleated specimens. There was no evidence of extraocular extension. In one eye a retinal detachment persisted after multiple attempts at repair. Conclusion: Despite long activity-free interval, surgical intervention in monocular patients with retinoblastoma should be approached cautiously because of the potential for tumor reactivation.
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