December 2002
Volume 43, Issue 13
ARVO Annual Meeting Abstract  |   December 2002
CXCR4 Is Expressed on Vitreoretinal Membranes
Author Affiliations & Notes
  • L Cabay
    Ophthalmology CHU St Pierre Bruxelles Belgium
  • F Willermain
    Brussels Belgium
  • L Lespagnard
    Brussels Belgium
  • B Nowak
    Brussels Belgium
  • J-L Dargent
    Brussels Belgium
  • A Maho
    Brussels Belgium
  • Y Witta
    Washington WA
  • T Velu
    Brussels Belgium
  • L Casper-Velu
    Brussels Belgium
  • C Bruyns
    Brussels Belgium
  • Footnotes
    Commercial Relationships   L. Cabay, None; F. Willermain, None; L. Lespagnard, None; B. Nowak, None; J. Dargent, None; A. Maho, None; Y. Witta, None; T. Velu, None; L. Casper-Velu, None; C. Bruyns, None.
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 2614. doi:
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    • Get Citation

      L Cabay, F Willermain, L Lespagnard, B Nowak, J-L Dargent, A Maho, Y Witta, T Velu, L Casper-Velu, C Bruyns; CXCR4 Is Expressed on Vitreoretinal Membranes . Invest. Ophthalmol. Vis. Sci. 2002;43(13):2614.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract: : Purpose:To investigate if the chemokine receptor CXCR4 is expressed in vitreoretinal membranes from Proliferative vitreoretinopathy (PVR) and macular pucker (MP). Methods:Membranes (3 PVR and 3 puckers) were surgically removed and immunohistochemistry with antibody recognising CXCR4, cytokeratin (CK), smooth muscle actin (SMA) and GFAP were performed. Results:: Membranes from PVR displayed a higher cellular density compared with MP. CXCR4, CK, SMA and GFAP were expressed in both types of membranes, but with variable intensities from one to another specimens. Conclusion:We show that CXCR4 is expressed in vitreoretinal membranes.. Further experiments need to be performed to test if CXCR4 (and other chemokine receptors) is implicated in vitreoretinal membrane formation.

Keywords: 524 proliferative vitreoretinopathy • 380 cytokines/chemokines • 434 immunohistochemistry 

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