Abstract
Abstract: :
Purpose:To investigate if the chemokine receptor CXCR4 is expressed in vitreoretinal membranes from Proliferative vitreoretinopathy (PVR) and macular pucker (MP). Methods:Membranes (3 PVR and 3 puckers) were surgically removed and immunohistochemistry with antibody recognising CXCR4, cytokeratin (CK), smooth muscle actin (SMA) and GFAP were performed. Results:: Membranes from PVR displayed a higher cellular density compared with MP. CXCR4, CK, SMA and GFAP were expressed in both types of membranes, but with variable intensities from one to another specimens. Conclusion:We show that CXCR4 is expressed in vitreoretinal membranes.. Further experiments need to be performed to test if CXCR4 (and other chemokine receptors) is implicated in vitreoretinal membrane formation.
Keywords: 524 proliferative vitreoretinopathy • 380 cytokines/chemokines • 434 immunohistochemistry