December 2002
Volume 43, Issue 13
Free
ARVO Annual Meeting Abstract  |   December 2002
Distribution of Areas of Low Flow in the Retinal Peripapillary Blood Flow of Elderly Population
Author Affiliations & Notes
  • LV Mavroudis
    AUTH Thessaloniki Greece
  • A Harris
    Glaucoma Research and Diagnostic Center Indiana University Indianapolis IN
  • AL Coleman
    Center for Eye Epidemiology Jules Stein Eye Institute UCLA School of Medicine LA CA
  • F Topouzis
    AUTH Thessaloniki Greece
  • F Yu
    Center for Eye Epidemiology Jules Stein Eye Institute UCLA School of Medicine LA CA
  • L Kagemann
    Glaucoma Research and Diagnostic Center Indiana University Indianapolis IN
  • E Anastasopoulos
    AUTH Thessaloniki Greece
  • A Koskosas
    AUTH Thessaloniki Greece
  • NT Stangos
    AUTH Thessaloniki Greece
  • MR Wilson
    Creighton University Omaha NE
  • Footnotes
    Commercial Relationships   L.V. Mavroudis, None; A. Harris, None; A.L. Coleman, None; F. Topouzis, None; F. Yu, None; L. Kagemann, None; E. Anastasopoulos, None; A. Koskosas, None; N.T. Stangos, None; M.R. Wilson, None. Grant Identification: International Glaucoma Association, UCLA CEE, Glaucoma Res Edu Found - Indiana Un, Pharmacia Hellas
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 2619. doi:
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    • Get Citation

      LV Mavroudis, A Harris, AL Coleman, F Topouzis, F Yu, L Kagemann, E Anastasopoulos, A Koskosas, NT Stangos, MR Wilson; Distribution of Areas of Low Flow in the Retinal Peripapillary Blood Flow of Elderly Population . Invest. Ophthalmol. Vis. Sci. 2002;43(13):2619.

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Abstract

Abstract: : Purpose: To study the distribution of areas of low flow and the inter-eye and intra-eye blood flow relationships in a random sample of older individuals. Methods: Blood flow measurements were performed in both eyes of 240 subjects from a sample of 251 subjects (age 60-88 years, mean 70.5 years) participating in a population based study. 13 subjects with glaucoma, 6 with migraine and 6 under glaucoma medications were excluded form the analysis. Heidelberg retina flowmeter was used to record capillary perfusion in the superotemporal and inferotemporal peripapillary region in both eyes. Pixel by pixel analysis was done in an area adjacent to the optic disc, with a minimum of 1600 pixels. The percentage of pixels with no flow (0 pixels), mean flow, and 10, 25, 50, 75, 90 percentiles of flow values were calculated. Correlation analysis was done between right and left eyes, between superior temporal (ST) and inferior temporal (IT) flow values and between IOP, perfusion pressure (PP) and blood flow parameters. Results: IOP and PP were not significantly correlated with any of the blood flow parameters. Correlations between eyes (LE and RE) and between ST and IT.  

Conclusion: In normal individuals older than 60 years of age, there is a correlation in most of blood flow parameters in ST and in IT between the right and left eyes as measured with the HRF. Interestingly, there is no correlation in the low blood flow values between ST and IT in the same eye. Thus, there may be more differences in blood flow among the different regions of an eye than between two eyes of an individual. There may be a central regulatory mechanism that accounts for the observed association in blood flow in the same location between the two eyes of an individual.

Keywords: 331 blood supply • 309 aging • 432 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) 
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