December 2002
Volume 43, Issue 13
Free
ARVO Annual Meeting Abstract  |   December 2002
Dynamic Light Scattering changes in the molecular structure of the macula in patients with advanced Age-Related Macular Degeneration
Author Affiliations & Notes
  • V Sturm
    Ophthalmology University of Hamburg Hamburg Germany
  • J Carstens
    Ophthalmology University of Hamburg Hamburg Germany
  • E Poerksen
    Ophthalmology University of Hamburg Hamburg Germany
  • S Pressmar
    Ophthalmology University of Hamburg Hamburg Germany
  • N Schmitz
    Ophthalmology University of Hamburg Hamburg Germany
  • G Richard
    Ophthalmology University of Hamburg Hamburg Germany
  • F Fankhauser
    Ophthalmology University of Hamburg Hamburg Germany
  • Footnotes
    Commercial Relationships   V. Sturm, None; J. Carstens, None; E. Poerksen, None; S. Pressmar, None; N. Schmitz, None; G. Richard, None; F. Fankhauser, None.
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 2799. doi:
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    • Get Citation

      V Sturm, J Carstens, E Poerksen, S Pressmar, N Schmitz, G Richard, F Fankhauser; Dynamic Light Scattering changes in the molecular structure of the macula in patients with advanced Age-Related Macular Degeneration . Invest. Ophthalmol. Vis. Sci. 2002;43(13):2799.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: Dynamic Light Scattering (DLS) as a non-invasive optical probe is a useful instrument for in vivo molecular diagnostics in the human eye. In this pilot study DLS was used to demonstrate the detectability of changes in the molecular structure of the macula in patients with advanced Age-Related Macular Degeneration (AMD). Methods: Baseline DLS-measurements of the macular region were performed in two young male volunteers who underwent 30 minutes of dark adaption before and after presenting a supra treshold light stimulus. The same procedure was repeated on 2 male patients with Subfoveal Choroidal Neovascularization (CNV). Results: There was a distinct difference of the autocorrelation functions between the volunteers and the CNV patients. According to DLS-data there seems to be a possibility of different concentrations of macroproteins within the macular area. Conclusion: DLS seems to be a suitable tool for the observation of protein changes in the fovea of patients with AMD. Due to the limited number of cases, statistically significant results are not yet available. Our ongoing investigations involving a larger number of cases looking at different stadiums of AMD may reveal the power of DLS for diagnosis of AMD at an early moment.

Keywords: 308 age-related macular degeneration • 527 protein structure/function • 356 clinical (human) or epidemiologic studies: systems/equipment/techniques 
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