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V Sturm, J Carstens, E Poerksen, S Pressmar, N Schmitz, G Richard, F Fankhauser; Dynamic Light Scattering changes in the molecular structure of the macula in patients with advanced Age-Related Macular Degeneration . Invest. Ophthalmol. Vis. Sci. 2002;43(13):2799.
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Purpose: Dynamic Light Scattering (DLS) as a non-invasive optical probe is a useful instrument for in vivo molecular diagnostics in the human eye. In this pilot study DLS was used to demonstrate the detectability of changes in the molecular structure of the macula in patients with advanced Age-Related Macular Degeneration (AMD). Methods: Baseline DLS-measurements of the macular region were performed in two young male volunteers who underwent 30 minutes of dark adaption before and after presenting a supra treshold light stimulus. The same procedure was repeated on 2 male patients with Subfoveal Choroidal Neovascularization (CNV). Results: There was a distinct difference of the autocorrelation functions between the volunteers and the CNV patients. According to DLS-data there seems to be a possibility of different concentrations of macroproteins within the macular area. Conclusion: DLS seems to be a suitable tool for the observation of protein changes in the fovea of patients with AMD. Due to the limited number of cases, statistically significant results are not yet available. Our ongoing investigations involving a larger number of cases looking at different stadiums of AMD may reveal the power of DLS for diagnosis of AMD at an early moment.
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