December 2002
Volume 43, Issue 13
ARVO Annual Meeting Abstract  |   December 2002
Supradescemetic Keratoprosthesis (SD-KPro): A Novel Design
Author Affiliations & Notes
  • SL Kaminski
    Ophthalmology University of Vienna (AKH) Vienna Austria
  • e Lacombe
    Rothschild Foundation Paris France
  • b Duchesne
    CHU Sart-Tilman Liege Belgium
  • v Fernandez
    Biophysics Center BPEI Miami FL
  • p Lamar
    Biophysics Center BPEI Miami FL
  • w Lee
    Biophysics Center BPEI Miami FL
  • f Manns
    Biophysics Center BPEI Miami FL
  • e Alfonso
    Biophysics Center BPEI Miami FL
  • j-M Parel
    Biophysics Center BPEI Miami FL
  • Footnotes
    Commercial Relationships   S.L. Kaminski, None; E. Lacombe, None; B. Duchesne, None; V. Fernandez, None; P. Lamar, None; W. Lee, None; F. Manns, None; E. Alfonso, None; J. Parel, None. Grant Identification: Support: Florida Lions Eye Bank, European project BMH4-CT97-9507, Research to Prevent Blindness NY,
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 2993. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      SL Kaminski, e Lacombe, b Duchesne, v Fernandez, p Lamar, w Lee, f Manns, e Alfonso, j-M Parel; Supradescemetic Keratoprosthesis (SD-KPro): A Novel Design . Invest. Ophthalmol. Vis. Sci. 2002;43(13):2993.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Abstract: : Purpose: To assess feasibility, mechanical stability and biocompatibility of a new SD-KPro. Methods: The mesoplant optical zone (8mm radius of curvature, 4.5mm diameter, 450µm thick) has a conical base with 100µm thick 1.25mm wide annular skirt with 18 perforations for tissue ingrowth and nutrient transfer. Four materials were tested: hydrophobic PMMA and hydrophilic pHEMA-MMA26, pHEMA-MMA34 and pHEMA-NV75 (number =%H2O). In 58 adult NZW rabbits, after a superior limbal incision, Descemet's membrane was identified and a centripetal delamination performed. A custom-made shield was inserted and the trephination done with 3.98 or 3.51 mm handheld vacuum trephines. The SD-KPro was either inserted through the trephination opening or via the delaminated tunnel. Antibiotic eye drops were administered tid for 3 days postop. The eyes were daily examined at the slit-lamp for the first week and weekly thereafter. Animals were euthanized only in cases of impending extrusion, massive inflammation or other adverse reactions. Results: With our technique, accurate delamination was easy, a 90 % average depth achieved, and only 8 perforations occurred intraoperatively. Implantation was easy in all cases and the new SD-KPro didn't require sutures or glue for fixation. In this ongoing study, overall retention time (RT) for all 4 materials is 89.7 ± 73.9days (range, 7 to 276days) with mean RTs of: PMMA =131 ± 93.7days (max 253), pHEMA-MMA26 = 76.6 ± 41.6days (max 230), pHEMA-MMA34 =160.7 ± 109.2days (max 276), HEMA- NVP75 =70.8 ± 30.0days (max 162). Histology of 9 excised specimen (between 3 to 50 weeks postop) showed epithelial down growth surrounding the implants and a rarification of the epithelium close to the optic and over the annular skirt. Conclusion: The new SD-KPro design in conjunction with the new delamination technique improved mechanical stability and retention time. The pHEMA-NV75 was found opto-mechanically similar to, and highly biocompatible with, the cornea.

Keywords: 451 keratoprostheses • 316 animal model 

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.