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M-H Park, C-S Jung, J Lee, W Choi, S Chung, N Baek; The Effect of Basic Fibroblast Growth Factor on the Vascularization of Porous Orbital Implant . Invest. Ophthalmol. Vis. Sci. 2002;43(13):3049.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: With the use of porous obital implants hydroxyapatite and synthetic polyethylene orbital implants(Medpor(R)) movable artificial eyes were made possible. But on the other hand, vascularization into the implant is reported to be associated with complications such as exposure and infection. In this study, we investigated the vascularization of Medpor(R) using an angiogenic factor, basic fibroblast growth factor(bFGF). Methods: After evisceration, Medpor(R) was inserted into 18 eyes of 18 New Zealand white rabbits. Medpor(R) soaked with bFGF was used in 9 eyes and unsoaked Medpor(R) in the other 9 eyes. Three eyeballs each were removed in the two groups at 1,2, and 4 weeks. Removed eyeballs were served at the equator and stained with H&E and Maisson trichrome. We classified the degree of vascularization into zone 1(/= 4.6mm ingrowth). The vascularized area was yielded as a percentage and was statistically analyzed Results: The rate of vascularization was significantly higher in the bFGF soaked group (84.38%) than in the control group(66.25%)(p=0.027, student t test). Conclusion: BFGF is thought to be useful in increasing vascularization of porous orbital implants.
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