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RD Allen DO, DE E Holck MD, JD Ng MD, K Dacey MD, S Blaydon MD, S Demartelaere MD, F Scribbick MD, J Foster MD; Synthetic Bone Graft Particulate Increases the Rate of Fibrovascular Ingrowth in Spherical Porous Polyethylene Orbital Implants . Invest. Ophthalmol. Vis. Sci. 2002;43(13):3050.
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Purpose: To evaluate the effect of placing synthetic bone glass particulate in spherical porous polyethylene orbital implants in a population of New Zealand white rabbits. Methods: 48 New Zealand albino white rabbits underwent enucleation of their right eyes. Twenty-four of the subjects received a 12mm diameter porous polyethylene orbital implant, and twenty-four received a 12 mm diameter porous polyethylene orbital implant containing 30% by weight synthetic bone glass particulate. Six subjects from each group were sarificed at weekly intervals and the implants removed. These implants were sectioned and stained for histologic examination. Assessments were made of the depth and density of fibrovascular ingrowth and statistically evaluated using the Pearson chi-square test. Results: None of the subjects experienced implant exposure, extrusion, significant clinical inflammatory response or infection during the course of the study. The synthetic bone glass particulate-imbedded implants showed a greater depth of fibrovascular ingrowth, higher density of fibrovascular ingrowth by two weeks and vascularized at a faster rate than the standard porous polyethylene implants. Conclusion: This study suggests that synthetic bone glass particulate imbedded in porous polyethylene spherical orbital implants increases the rate and density of fibrovascular ingrowth into standard porous polyethylene orbital implants in the first few weeks after implantation. With acceleration of fibrovascular ingrowth, this material may offer benefit to porous orbital implants.
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