Abstract
Abstract: :
Purpose: To study the leading indications and changing trends for penetrating keratoplasty over the past two decades. Methods: The pathologic indications for all penetrating keratoplasties performed at the Duke University Eye Center during January 1, 1980 through December 31 1981; January 1,1990 through December 31, 1991; and January 1, 2000 through October 31, 2001 were reviewed. Each group of two-year intervals served as the basis for comparison. Results: The following summarizes our findings. Leading Pathologic Diagnosis for Penetrating Keratoplasty by Decade The remainder of the penetrating keratoplasties performed during 1980-1981 included neoplasms 5 (2.7), keratitis 8 (4.3), perforation 3 (1.6), rheumatoid arthritis 1 (0.5), scar 13 (7.0), trauma 12 (6.5), ulcer 9 (4.8), vascularization 6 (3.2), and other 10 (5.3). The remainder performed during 1990-1991 included neoplasms 7 (2.2), keratitis 21 (6.7), perforation 7 (2.2), rheumatoid arthritis 9 (2.9), scar 28 (8.9), trauma 3 (1.0), ulcer 14 (4.4), vascularization 6 (1.9), and other 22 (7.0). The remainder of cases during 2000-2001 included keratitis 2 (0.6), perforation 2 (0.6), scar 28 (8.5), trauma 7 (2.1), ulcer 13 (4.0), and other 28 (8.5). Conclusion: Currently failed graft, Fuchs' dystrophy, and pseudophakic/aphakic bullous keratopathy are the three most common indications of penetrating keratoplasty. Although in 1980-1981 and 1990-1991 pseudophakic/aphakic bullous keratopathy was the most common indication for penetrating keratoplasty, in 2000-2001 it has dropped to number three. An explantaion for this trend remains to be determined, but it probably reflects improvements in the techniques of cataract surgery and better intraocular lenses.
Keywords: 369 cornea: clinical science • 607 transplantation • 354 clinical (human) or epidemiologic studies: prevalence/incidence