December 2002
Volume 43, Issue 13
ARVO Annual Meeting Abstract  |   December 2002
Topical Treatment For Epithelial Herpetic Keratitis: Ganciclovir Gel Vs Aciclovir Ointment
Author Affiliations & Notes
  • JB Ramirez
    Cornea Department Hosp Nuestra Senora De La Luz Mexico City Mexico
  • O Baca
    Mexico City Mexico
  • R Velasco
    Mexico City Mexico
  • D Viggiano
    Mexico City Mexico
  • J Erazo
    Mexico City Mexico
  • Footnotes
    Commercial Relationships   J.B. Ramirez, None; O. Baca , None; R. Velasco , None; D. Viggiano , None; J. Erazo , None.
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 3072. doi:
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      JB Ramirez, O Baca, R Velasco, D Viggiano, J Erazo; Topical Treatment For Epithelial Herpetic Keratitis: Ganciclovir Gel Vs Aciclovir Ointment . Invest. Ophthalmol. Vis. Sci. 2002;43(13):3072.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract: : Purpose:To evaluate the therapeutic effectiveness and local tolerance of the 0.15% ganciclovir gel versus 3% acyclovir ointment in the treatment of epithelial herpetic keratitis. Methods:Twenty seven patients with epithelial herpetic keratitis diagnosis were included. All patients selected had a clinical course less than 8 days and were over fifteen years old. Patients with severe stromal involvement, uveitis or methaherpetic ulcer were excluded. Two treatment groups were stablished: one with ganciclovir gel (group 1) and one with acyclovir ointment (group 2). A single observer evaluated the healing rate, the mean healing time and the adverse effects of both drugs. Results:Nineteen patients were assessed: Ten patients in group 1 and nine patients for group 2; eight patients were excluded secondarily. The healing rate was 71% for group one and 69.2% for group two. The mean healing time was 9 days for group 1 and 10 days for group 2. The adverse effects were: discomfort and local irritation. Local tolerance was found to be superior in group 1 with less complaints of discomfort and without signs of local irritation. Conclusion:Ganciclovir gel is as good as the acyclovir ointment for the treatment of epithelial herpetic keratitis with a superior comfort and without local irritation this last facts will improve the treatment compliance, and therefore, a shorter course of the epithelial disease.

Keywords: 322 antiviral drugs • 425 herpes simplex virus • 353 clinical (human) or epidemiologic studies: outcomes/complications 

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