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MA Bullimore, M Nguyen, J Bozic, GL Mitchell; Overnight Corneal Swelling with 7-day Continuous Wear of Soft Contact Lenses . Invest. Ophthalmol. Vis. Sci. 2002;43(13):3100.
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Purpose: The goal was to evaluate the degree of overnight corneal swelling and the time course of deswelling following one night and seven consecutive nights of wearing silicone-hydrogel and conventional hydrogel contact lenses. Methods: Ten subjects were examined and fitted with PureVision (Balafilcon A, Bausch and Lomb, Rochester, New York) and Acuvue 2 (Etafilcon A, Vistakon, Jacksonville, Florida) lenses. Subjects wore each type of lenses in both eyes for seven consecutive days and nights. The order in which lenses were worn was randomized and each period of wear was separated by one-week washout period. Corneal thickness was measured using the Orbscan prior to lens wear and after lens insertion. Subjects slept in the College of Optometry for the first and seventh nights of lens wear. The following morning, corneal thickness was measured at 0, 5, 10, 15, 30, 60, 120, 240, and 360 minutes following eye opening. Overnight swelling was also assessed with the subjects wearing no lenses. Results: There was a significant difference in the amount of overnight corneal swelling after one night of lens wear (No lens: 1.18 2.8%; PureVision: 3.14 4.8%; Acuvue 2: 8.99 4.1%; F = 16.71; p < 0.0001). Similar results were observed after seven continuous nights of lens wear (PureVision: 2.78 5.1%; Acuvue 2: 8.46 2.9%; F = 25.85; p < 0.0001). The corneal swelling associated with Acuvue 2 wear was significantly higher than that with PureVision wear and no lens wear (p < 0.05) through 120 minutes following eye opening. Corneal thickness returned to baseline values in 60 minutes with PureVision compared to 360 minutes with Acuvue 2 (p < 0.05). Conclusion: As would be expected from the physical properties of the lens materials, the PureVision lens induced less overnight corneal swelling and allowed the cornea to return to baseline thickness more rapidly than the Acuvue 2 lens.
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