December 2002
Volume 43, Issue 13
Free
ARVO Annual Meeting Abstract  |   December 2002
Effect of Designer Polymers on Tear Break-up Time in the Rat
TJ Millar; K Peters; GR Dennis; PJ Anderton
Author Affiliations & Notes
  • TJ Millar
    School of Science Food and HorticultureCo-operative Research Centre for Eye Research and Technology University of Western Sydney Penrith South DC Australia
  • K Peters
    School of Science Food and HorticultureCo-operative Research Centre for Eye Research and Technology University of Western Sydney Penrith South DC Australia
  • GR Dennis
    School of Science Food and HorticultureCo-operative Research Centre for Eye Research and Technology University of Western Sydney Penrith South DC Australia
  • PJ Anderton
    Co-operative Research Centre for Eye Research and Technology University of NSW Sydney Australia
  • Footnotes
    Commercial Relationships   T.J. Millar, None; K. Peters, None; G.R. Dennis, None; P.J. Anderton, None. Grant Identification: Support: The Australian Government Co-operative Research Programs
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 3120. doi:
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      TJ Millar, K Peters, GR Dennis, PJ Anderton; Effect of Designer Polymers on Tear Break-up Time in the Rat . Invest. Ophthalmol. Vis. Sci. 2002;43(13):3120.

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Abstract

Abstract: : Purpose: To investigate the effect of structurally different lipid-like polymers and co-polymers on tear film stability of the rat. Methods: Non-crosslinked polymers of defined molecular weights were synthesised and mixed with a test solution of tears and saline and applied to the corneal surface. The performance of the tear film was measured by specular reflection microscopy. Polymers tested were: polytertiary-butylacrylate (PTBA); polymethylacrylate-co-polyacrylic acid (PMA-PAA); polystyrene PS); carboxyl terminated polystyrene (CPS); poly N-butyl acrylate (PNBA); polytertiary-butylacrylate-co-polystyrene (PTBA-PS); polyvinyl alcohol (PVA); and polyacrylic acid of three different molecular weights (PAA-2, PAA-3, PAA-5) Results: Phosphatidylcholine and phosphatidyl inositol controls gave tear break-up times similar to tears plus saline alone 90-120s. The more hydrophilic polymers (such as the PAAs), destabilised the tear film, so that tear break-up was faster than controls. Copolymers consisting of separate hydrophobic and hydrophilic regions appeared to be the best stabilisers, extending break-up time to more than 10 minutes. Conclusion: More hydrophobic polymers stabilised the tear film better than hydrophilic polymers. The copolymers PTBA-PS and PMA-PAAC were the most effective stabilisers with the more hydrophobic, PTBA-PS, giving the best performance.

Keywords: 376 cornea: tears/tear film/dry eye • 458 lipids 
© 2002, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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