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TJ Millar, K Peters, GR Dennis, PJ Anderton; Effect of Designer Polymers on Tear Break-up Time in the Rat . Invest. Ophthalmol. Vis. Sci. 2002;43(13):3120.
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Purpose: To investigate the effect of structurally different lipid-like polymers and co-polymers on tear film stability of the rat. Methods: Non-crosslinked polymers of defined molecular weights were synthesised and mixed with a test solution of tears and saline and applied to the corneal surface. The performance of the tear film was measured by specular reflection microscopy. Polymers tested were: polytertiary-butylacrylate (PTBA); polymethylacrylate-co-polyacrylic acid (PMA-PAA); polystyrene PS); carboxyl terminated polystyrene (CPS); poly N-butyl acrylate (PNBA); polytertiary-butylacrylate-co-polystyrene (PTBA-PS); polyvinyl alcohol (PVA); and polyacrylic acid of three different molecular weights (PAA-2, PAA-3, PAA-5) Results: Phosphatidylcholine and phosphatidyl inositol controls gave tear break-up times similar to tears plus saline alone 90-120s. The more hydrophilic polymers (such as the PAAs), destabilised the tear film, so that tear break-up was faster than controls. Copolymers consisting of separate hydrophobic and hydrophilic regions appeared to be the best stabilisers, extending break-up time to more than 10 minutes. Conclusion: More hydrophobic polymers stabilised the tear film better than hydrophilic polymers. The copolymers PTBA-PS and PMA-PAAC were the most effective stabilisers with the more hydrophobic, PTBA-PS, giving the best performance.
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