December 2002
Volume 43, Issue 13
Free
ARVO Annual Meeting Abstract  |   December 2002
Cromoglicic Acid Ophthalmic Solution 2% Versus Levocabastine Ophthalmic Suspension 0.025% in the Treatment of Allergic Conjunctivitis
Author Affiliations & Notes
  • T Kawakita
    Ophthalmology Tokyo Dental College Ichikawa Japan
  • Y Takano
    Ophthalmology Tokyo Dental College Ichikawa Japan
  • M Tanaka
    Ophthalmology Tokyo Dental College Ichikawa Japan
  • N Asano-Kato
    Ophthalmology Tokyo Dental College Ichikawa Japan
  • K Fukagawa
    Ophthalmology Tokyo Dental College Ichikawa Japan
  • K Tsubota
    Ophthalmology Tokyo Dental College Ichikawa Japan
  • H Fujishima
    Ophthalmology Tokyo Dental College Ichikawa Japan
  • Footnotes
    Commercial Relationships   T. Kawakita, None; Y. Takano, None; M. Tanaka, None; N. Asano-Kato, None; K. Fukagawa, None; K. Tsubota, None; H. Fujishima, None.
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 3168. doi:
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    • Get Citation

      T Kawakita, Y Takano, M Tanaka, N Asano-Kato, K Fukagawa, K Tsubota, H Fujishima; Cromoglicic Acid Ophthalmic Solution 2% Versus Levocabastine Ophthalmic Suspension 0.025% in the Treatment of Allergic Conjunctivitis . Invest. Ophthalmol. Vis. Sci. 2002;43(13):3168.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To compare a ocular cromoglicic acid (Intal Ophthalmic Solution 2%; Fisons, England), with ocular antihistamine, levocabastine hydrochloride (Livostin Ophthalmic Suspension 0.05%; Janssen, Belgium), in the treatment of allergic conjunctivitis using symptoms and signs scale. Methods:A total of 23 subjects with a history of allergic conjunctivitis and a positive response to a diagnostic test were valuable for safety analysis, and 23 subjects were valuable for the efficacy analysis. We performed a prospective, contralateral eye study comparing cromoglicic acid 2% in one eye with levocabastine 0.025% in the contralateral eye. Efficacy was determined 1 week after administration of study medications. Symptoms (Ocular itching, discharge, redness, lacrimation and nasal discharge) and signs score (conjunctival injection, edema, papilla, eyelid swelling and corneal change) were recorded before and 1 week after eye drop treatment. Results:Twelve patients (52.2%) selected levocabastine, 3 patients (13.0%) selected Cromoglicic acid and 8 patients evaluated to be even. Levocabastine 0.025% was statistically significantly effective more than cromoglicic acid 2% in reducing ocular itching (p=0.007) and papilla formation (p=0.02). Cromoglicic acid 2% and levocabastine 0.025% were statistically equivalent in reducing other symptoms and signs scores. Conclusion:Levocabastine 0.025% is significantly favorable and effective more than cromoglicic acid 2% in reducing ocular itching associated with allergic conjunctivitis. The two compounds are equivalent in controlling the other symptoms associated with allergic conjunctivitis.

Keywords: 366 conjunctivitis • 357 clinical (human) or epidemiologic studies: treatment/prevention assessment/controlled clinical trials • 436 injection 
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